Useful Info (Original Patient Education) JASE Medical - Page 23
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Avoid Exposure to Infectious Diseases by Accessing this Medical Model

With emergency room department waiting times ranging from just over one and a half hours (North Dakota) to just under 4 hours, (Maryland) the likelihood that you will be exposed to contagious diseases in crowded waiting rooms is almost certain.

 From urinary tract infections to respiratory infections (pneumonia, covid, influenza and others) to gastrointestinal illnesses (diarrhea and vomiting) to hospital acquired infections,  the waiting room in the emergency department is a cesspool of infectious agents.

It is estimated that up to one in four ER visits are unnecessary or could be handled via doctors office or urgent care visits. In addition, the CDC estimates that 42 percent of the US population visits the ER annually. Given the long wait times in the ER waiting rooms, this is a massive number of potentially unnecessary exposures to infectious diseases.

 To put this in perspective, this calculates to approximately 3.48 million ER visits that could be handled by urgent care or doctor’s office visit Even with shorter waiting times (average wait time in doctors waiting room is 18 minutes) you are still exposed to other sick people for an extended period of time.

The most common reasons for an ER visit as of 2020 are:

  • Abdominal pain
  • Chest pain
  • Fever
  • Shortness of breath
  • Cough
  • Pain, non-specific
  • Psychiatric disorders
  • Back pain
  • Accidents

While many of these visits are true emergencies, a sizeable number are preventable.

Healthcare worker shortage

Along with extended wait times, the US is facing an unprecedented healthcare worker shortage.

The pandemic put a tremendous strain on the healthcare population, many report burnout as a factor for leaving. In addition, the workforce is aging faster than the replacement rate of qualified workers.

Both these statistics point to compromised patient care, The remaining workers are stretched to their limit, working long hours, leaving them exhausted both mentally and physically.

A viable and highly effective option to non-emergent in person visits is telemedicine

Telehealth — sometimes called telemedicine — lets your health care provider care for you without an in-person office visit. Telehealth is done primarily online with internet access on your computer, tablet, or smartphone.

Telehealth visits can range from:

  • Strains and sprains
  • Allergies and asthma management
  • Flu symptoms
  • Diarrhea
  • Vomiting
  • Monitor chronic health conditions such as arthritis, and blood pressure.
  • Medication refills
  • Order labs and x rays as necessary
  • The telehealth provider can triage and advise if an ER or in-person visit is warranted.

Cons of telehealth

  • Should never be used as emergency care
  • Should not be used in place of in office visits
  • Some populations may not be familiar with digital access and how to use. There can be a learning curve.

There are several ways to utilize telehealth care:

  • Speak to your health care provider live over the phone or video chat.
  • Send and receive messages from your health care provider using secure messaging, email, secure messaging, and secure file exchange.
  • Use remote monitoring so your health care provider can check on you at home. For example, you might use a device to gather vital signs to help your health care provider stay informed on your progress.

Advantage of telehealth visits

  • Avoids exposure to infectious diseases by avoiding waiting rooms.
  • Saves transportation costs and time traveling.
  • Can save time accessing medical care.
  • Many health insurance plans now cover these types of visits.

Your healthcare provider may already be providing telehealth services. Check with them and see if this is an option. In addition, check with your healthcare insurance provider and inquire if they cover telehealth visits.

- Brooke Lounsbury, RN

Medical Content Writer

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Hashimotos Thyroiditis Part 2

Tips to manage Hashimoto’s

  • Health risks of not treating Hashimoto’s adequately
  • Lifestyle/stress reduction tips to manage energy and emotional ups and downs
  • How to naturally increase biologically active T3
  • Diet strategies to help heal
  • Nutritional supplements that can aid in recovery and optimal health
  • How to advocate for yourself in the healthcare field when dealing with Hashimoto’s

Health risks of not treating Hashimoto’s adequately

  • May cause impaired carbohydrate metabolism leading to an increase in type 1 and type 2 diabetes- A study that examined hospitalized patients between the years of 2001 and 2010, the Endocrinology and Diabetology Department in Bydgoszcz concluded : “Conclusions: Carbohydrate metabolism disorders in the form of type 1 diabetes connected with an autoimmune process, as well as type 2 diabetes connected with the increase of the insulin resistance, occurred in average of half of the patients with Hashimoto’s thyroiditis.”
  • Cognitive decline/brain fog, inability to focus, – Hashimoto’s thyroiditis is an inflammatory disease (hence the “itis” at the ending of thyroiditis) This extends to brain tissue, where brain inflammation can cause a multitude of problems.
  • Fertility issuesAn unregulated thyroid condition of any kind can lead to lack of or incomplete implantation or early miscarriage. Thyroid disorders in men can affect sperm quality and motility
  • Higher risk of heart disease and high cholesterol

A large study in Demark over a period of 7 years revealed that   individuals with mild hypothyroidism who were not treated had an 83% increased risk of developing heart problems as compared with individuals with normal thyroid function or hypothyroidism that was treated. 

High cholesterol – Low thyroid function negatively affects lipid metabolism, leading to an increase LDL, the “bad cholesterol.”

Lifestyle/stress reduction tips to manage energy and emotional ups and downs

Hashimoto’s disease can have you feeling great one day and totally exhausted the next. Even when optimally managed, excess stress, either emotional or physical can leave one feeling exhausted for days. It is important to maintain good diet, adequate exercise, avoid stress as much as possible and keep a consistent schedule.

  • Remove/reduce sugar from the diet as much as possible, replace with fiber rich fruits. Sugar can place a tremendous burden on the body, flooding cells with insulin to deal with excess glucose in the bloodstream. This can set off a cascade of reactions that challenge thyroid regulation and can affect fat cell receptors and metabolism.
  • Make time for exercise-Make sure you are getting at least 15 minutes of brisk walking in a day. However, don’t overdo any physical activity. This can cause adrenal fatigue, cortisol overload and other stressors that can create a cascading downward spiral resulting in an overload on thyroid function.
  • Plan your days, but don’t over plan. Make time in your schedule to eat a healthy diet, exercise and get good quality sleep. In addition, make relationships and community a priority. Healthy relationships help carry life’s burdens and reduce stress hormones.
  • Get adequate, good quality sleep- The body repairs, heals and detoxifies during sleep. Good quality sleep is vital for Hashimoto patients. Aim for at least 7 hours of shut eye.
  • Keep stress at a minimum. Overactive adrenals, cause by stress can lead to thyroid dysfunction, diabetes, heart disease and more. Nurture and maintain supportive relationships. Avoid news and media if it negatively affects you. Take up a hobby. Hobbies have proven to reduce stress and calm the mind.

How to naturally increase biologically active T3

T3, the biologically active thyroid form can be increased by:

  • Supplementing diet with selenium and zinc rich foods. A rich source of selenium can be found in Brazil nuts- you only need 1-2 a day, Zinc is found in shellfish, nuts, meats, legumes. If supplementing with either selenium or zinc consult your care provider. Selenium toxicity can cause kidney failure and heart attack or heart failure, zinc toxicity symptoms are nausea, dizziness, vomiting and can lead to copper deficiency and a decrease in HDL (good) cholesterol.
  • Adding healthy fats to your diet– flax, avocado, raw unsalted seeds, and nuts. These foods aid in helping cell receptors take up thyroid hormone.
  • Moderate exercise– Walking, jogging, swimming, tennis, biking, hiking in moderation helps overall thyroid function.
  • Liver detoxification– The liver is involved in the conversion of thyroid hormone and regulation. Some foods that can help detoxify the liver are onions, beetroot, apples, turmeric, leafy greens, tea and in moderation, coffee.
  • Add sea vegetables to your diet. Iodine is a key factor in thyroid function; however, iodine supplementation can be tricky. Too much or too little can negatively affect thyroid dysfunction. Sea salt and iodized salt in moderation along with adding kelp and seaweed powder to your meal can help provide iodine needed supplementation.
  • Drink plenty of good quality, fluoride free water- Filter your water, and if fluoridated use a filter that removes fluoride. Fluoride has an electrical affinity stronger than iodine and will bond to the tyrosine molecule (Thyroid hormone is comprised of tyrosine and iodine) This reduces the amount of thyroid hormone in the body.

 

Diet strategies to help heal

It is believed that impaired gastrointestinal tract (gut dysbiosis) and intestinal permeability are the main cause of Hashimotos. To learn more check out Dr Isabella Wentz book on Hashimotos Thyroiditis- the root cause. This book is a wealth of information to educate and empower anyone dealing with Hashimoto’s.

  • As stated above, avoid simple carbohydrates. Breakfast should include a quality high protein item and fruit or vegetable if desired. Some quality high protein foods are cold water fish (salmon, sardines, and tuna for example) grass fed and finished meats, eggs, and poultry.
  • Increase leafy greens and vegetables such as carrots, turnips,celery
  • Drink twice body weight in ounces of quality water.
  • Add healthy fats to your diet. Healthy fats include butter (no margarine) flax, raw, unsalted nuts and seeds, avocados, olive oil and cold-water fish such as salmon.
  • Add a digestive enzyme right before meals if you experience stomach issues.
  • Eat soy in moderation- Soy, if paired with iodine deficiency can inhibit thyroid function. Check ingredient labels on every packaged food item, including salad dressings, protein bars, ice cream etc. for added soy. Most nutritionists advise to limit soy, not cut it out completely.
  • Cruciferous vegetables- cabbage, broccoli, cauliflower, brussel sprouts etc. if eaten in excess can suppress thyroid function. These foods are packed with nutrition. Don’t cut them out completely, just don’t eat in excess.
  • Supplement with probiotics and fermented foods- Gut health-restoring the gut microbiome- is a large part of healing and managing Hashimoto’s
  • Do a trial run of going gluten free- It takes about 3 weeks for the body to adjust to a gluten free diet. Many report relief in digestive symptoms and less body aches after stopping gluten. In a select population, gluten consumption can trigger an immune reaction. This is because gluten contains a protein (gliadin) that resembles transglutaminase, an enzyme of the thyroid. In gluten sensitivity or celiac disease, the immune system mistakenly attacks the thyroid.
  • Some people react to casein which is found in cow milk, yogurt, some cheeses and supplements. Casein is very structurally similar to gluten(gliadin) and some people have a negative reaction to it, just like gluten.

Nutritional supplements that can aid in recovery and optimal health

Important-Check with your healthcare provider before taking supplements- many supplements can interact with medications you are currently taking

  • Selenium works in synergy with vitamin E to form active T3
  • Zinc- helps repair intestinal walls and stabilizes immune system.
  • Vitamin D with K2 (K2 aids calcium absorption to bones instead of going to arteries where calcium can build up, leading to heart attack and stroke.)
  • Vitamin C with bioflavonoids
  • Magnesium citrate
  • Iron in the form of ferritin- if iron deficient
  • Iodine
  • B complex (look for the methylated form of B12)
  • Probiotics
  • Betain with Pepsin- a natural gastric acid- many Hashimoto sufferers have low stomach acid
  • Digestive enzymes- hel break down fats, carbohydrates and protein. Many diagnosed with Hashimotos have problems digesting food.

 

How to advocate for yourself in the healthcare field when dealing with Hashimoto’s

Dealing with thyroid disorders can be a complicated and complex health issue. Many diseases mimic others- Some heart diseases may have undiagnosed thyroid function. This also is common with depression, anxiety, and other mental health disorders. Some medications can affect thyroid function. Diabetics have a higher incidence of thyroid disorders.

Educating yourself and seeking a health professional who understands  thyroid disorders is vital to overall wellbeing.

At the very minimum, request a TSH and free T4 lab if hypothyroid is suspected.

Keep a journal of food, activity, mood and physical symptoms that you have recorded for a week or so before your appointment. Include physical signs of hypothyroid you may be having. This will enable your care provider to provide the best care possible.  

- Brooke Lounsbury, RN

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

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More Deadly than Driving a Car

I recently had an interesting conversation with my hair stylist. She had just enrolled in college to become a licensed addiction counsellor. I asked her what why she chose that career. She said she was a former drug addict and was homeless for a short period of time and understood  lifestyle of those addicted to drugs. She has been clean for 2 plus years. During that time she received her license to cut hair and landed a job at the hair salon I frequent.

She was a wealth of information. After telling her I had ordered and recently received in the mail naloxone (Narcan) from the state (I live in Washington state, where you can order online here- it is free) and that I had been writing about the fentanyl crisis she piped up and informed me that more people died of fentanyl overdoses than motor vehicle crashes in 2021.

Intrigued, I looked up the statistics. She was correct. But the one glaring statistic was how many more perished from fentanyl overdoses compared to motor vehicle crashes.

According to USA Facts: “In 2021, 70,601 people died from a fentanyl overdose in the US. That figure is up 25% from 2020 and is nearly double the amount of fentanyl overdose deaths in 2019.”

And the USDOT reports  “NHTSA projects that an estimated 42,915 people died in motor vehicle traffic crashes last year, a 10.5% increase from the 38,824 fatalities in 2020.”

If my math is correct, 60 percent more people died from fentanyl overdose than in car crashes.

Fentanyl, a synthetic opioid analgesic was originally developed for pain management for cancer patients. It is 50-100 times stronger than morphine.

In recent times it has become a deadly street drug manufactured in the States and Mexico.

Not just illegal drug users are at risk for fentanyl overdose. The recent episode of a 10 month old baby who turned blue and limp from accidental fentanyl exposure after playing in the grass at a local park drives home the point of how widespread this epidemic has become. EMS was called and naloxone was administered. The child survived.

The toddlers’ parents warn parents to closely watch their children playing at any public park or playground. Foil packets and even spilled fentanyl in the form of powder on the grass may have been the way the toddler was exposed.

My naloxone/Narcan order arrived

I received my naloxone in the mail last week. The directions to administer were clear.

In the state I reside I had the choice of either injectable or nasal spray doses. I chose injectable because I felt there are many more sites to choose from to administer than just nasal passages (nasal spray).

As of August 2020, all 50 states and the District of Columbia have some form of a naloxone access law. The laws vary significantly by state.

To obtain naloxone, state by state resources website and information can be found here.

A few facts about Naloxone/Narcan:

Healthline has an excellent explanation and more detailed instructions on naloxone.

  • Naloxone is safe, if you administer and the patient isn’t experiencing a drug overdose there are no side effects.
  • Naloxone, blocks the effects of opioids in your body. This drug works to reverse the life-threatening symptoms that happen during an overdose. More than one dose may be necessary because there may be more opioid in the body than the naloxone can block.
  • Naloxone is only active in the body for 20 to 90 minutes, the effects of most opioids last longer. This means that the effects of naloxone are likely to wear off before the opioids are gone from the body.
  • Narcan comes in one dose, for any age- from toddler to adult
  • It’s important to note that Narcan is not a substitute for medical treatment. After giving Narcan to someone, call 911 right away, even if the person wakes up after getting Narcan.

- Brooke Lounsbury, RN

Medical Content Writer

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Everyone should be empowered to care for themselves and their loved ones during the unexpected.

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Hashimotos Thyroiditis Part 1

Part 1 will cover

  • Hashimoto’s description
  • Prevalence of Hashimoto’s
  • Symptoms of low thyroid (Is it Hashimotos?)
  • Other not as common hypothyroid conditions
  • Lab tests to diagnose Hashimoto’s
  • Medications to treat low thyroid/Hashimotos

Part 2 will cover:

Tips to manage Hashimoto’s along with medications such as

  • Health risks of not treating Hashimoto’s adequately
  • Lifestyle/stress reduction tips to manage energy and emotional ups and downs
  • How to naturally increase biologically active T3
  • Diet strategies to help heal
  • Nutritional supplements that can aid in recovery and optimal health
  • How to advocate for yourself in the healthcare field when dealing with Hashimoto’s

Description

Hashimoto’s thyroiditis is an autoimmune disease that affects the thyroid. An autoimmune disease is a condition in which the body’s immune system mistakes its own healthy tissues as foreign and attacks them. Most autoimmune diseases cause inflammation of the affected tissue. In the case of Hashimoto’s thyroiditis, the thyroid gland is inflamed and attacked by the body’s immune system.

Note: any word with “itis” at the end indicates inflammation. (Arthritis, bursitis, conjunctivitis for example)

Over 90% of hypothyroid cases are Hashimoto’s.

Other causes of low thyroid are:

 (Excerpt from American Thyroid Association)

  • Pituitary gland disorder/damage-The pituitary, the “master gland,” tells the thyroid how much hormone to make. When the pituitary is damaged by a tumor, radiation, or surgery, it may no longer be able to give the thyroid instructions, and the thyroid may stop making enough hormone.
  • Medicines-Medicines such as amiodarone, lithium, interferon alpha, and interleukin-2 can prevent the thyroid gland from being able to make hormone normally. These drugs are most likely to trigger hypothyroidism in patients who have a genetic tendency to autoimmune thyroid disease.
  • Too much or too little iodine. The thyroid gland must have iodine to make thyroid hormone. Iodine comes into the body in food and travels through the blood to the thyroid. Keeping thyroid hormone production in balance requires the right amount of iodine. Taking in too much iodine can cause or worsen hypothyroidism.
  • Surgical removal of part or all of the thyroid gland due to nodules or cancer
  • Radiation treatment-Patients with Hodgkin’s disease, lymphoma, or cancers of the head or neck are treated with radiation. All these patients can lose part or all of their thyroid function.
  • Congenital hypothyroidism (hypothyroidism that a baby is born with). A few babies are born without a thyroid or with only a partly formed one. A few have part or all their thyroid in the wrong place (ectopic thyroid). In some babies, the thyroid cells or their enzymes don’t work right.
  • Rare disorders that infiltrate the thyroid. In a few people, diseases deposit abnormal substances in the thyroid and impair its ability to function. For example, amyloidosis can deposit amyloid protein, sarcoidosis can deposit granulomas, and hemochromatosis can deposit iron.

Prevalence of Hashimoto’s

  • Most common in women– The American Thyroid Association (ATA) estimates that five to eight women are affected with Hashimoto’s for every one man. The ATA also estimates that one in eight women will be affected with Hashimoto’s or another thyroid disorder at some point in their lives.
  • Runs in families (genetic predisposition)
  • Affects about 5 percent of the US population
  • It is suspected that it is underdiagnosed

Symptoms

The onset of Hashimoto’s disease can be difficult to diagnose. As thyroid hormones are released in the bloodstream from  antibodies attacking the thyroid, transitory (temporary)hyperthyroidism (high thyroid) results.

Early symptoms can mimic hyperthyroid. This condition presents as an elevated T3 (the biologically active form of thyroid) and elevated T4, along with suppressed TSH. This condition is called thyrotoxicosis (Hashitoxicosis). This phase can last for 1-2 months, however in rare cases this phase can last for 2 or more years.

 Early-temporary symptoms can include

  • Anxiety
  • Nervousness
  • Diarrhea
  • Sleeplessness
  • Mood swings and muscle weakness.

 As the disease progresses (the autoimmune attack continues) thyroid production decreases, resulting in hypothyroidism (Hashimoto’s thyroiditis).

Symptoms of low thyroid are:

  • Dry skin,
  • Hair loss,
  • Constipation,
  • Depression,
  • Intolerance to cold,
  • Low energy
  • Brain fog,
  • Heavy menstruation,
  • Unexplained weight gain.
  • Muscle aches and cramps

Your care provider will take a thorough physical history (which includes checking for enlarged thyroid gland) and medical history along with a family history and your symptoms.

Lab tests for Hashimoto’s

TSH – The pituitary gland produces this hormone which stimulates the thyroid gland to produce thyroid hormone

Free T4– Free T4 is thyroid hormone not bound to protein, it is freely flowing in bloodstream.

Thyroid peroxidase antibodies (TPOAb) – Thyroid peroxidase (TPO) antibodies are a type of thyroid antibody. Thyroid peroxidase is an enzyme which helps to make thyroid hormones (T3, T4 and TSH). The body’s immune system makes antibodies in response to non-self proteins. These non-self proteins are called antigens.

Thyroglobulin antibodies (TGAb) Thyroglobulin antibodies (Tg Ab) are another type of thyroid antibody. Thyroglobulin is a protein made by thyroid cells. It helps to make thyroid hormones. Thyroglobulin antibodies (Tg Ab) are made when the body attacks it’s own thyroglobulin. Thyroglobulin antibodies can be raised in Hashimoto’s thyroiditis  They are also raised in 10-15% of the general population.

You may be diagnosed with Hashimoto’s disease if your TSH is high, your free T4 is low, and your TPO Ab is elevated. High TPO Ab is the key marker because it is present in over 90% of those with Hashimoto’s. TG Ab is present in about 60-80% of cases.

Total T3- as symptoms dictate

  • Low T3 levels may mean you have hypothyroidism,
  • T3 test results are often compared with T4 and TSH test results to help diagnose thyroid disease.

Reverse T3-as symptoms dictate

Reverse T3 is created by the body from T4. Your body can convert T4 into the ACTIVE thyroid hormone T3 or the inactive thyroid called reverse T3.  Reverse T3 slows metabolism to conserve energy during times of extreme stress and inflammation.

Treatment

Hashimoto’s requires a multi prong approach. Along with medication, and lifestyle/stress management, diet and supplements can go a long way to achieve optimum health.  Diet, lifestyle and supplements will be covered in part 2.

Medications

Note: A word about generic and label medications- Though the names are different, generic and brand-name drugs work the same. According to the FDA, generic drugs are just as effective as their branded counterparts. Drug makers must prove that generic medications can be substituted for brand-name drugs and offer the same benefits as their brand-name counterparts

Levothyroxine – also known as Synthroid Euthyrox, Unithroid,  Tirosint. and Levoxyl– These medications use only T4 hormone as primary ingredient.

One advantage to generic levothyroxine, unlike Synthroid is it does not contain corn. This is invaluable for anyone with an allergy or sensitivity to corn.

Armour thyroid- Desiccated thyroid- made from bovine thyroid hormone- contains both T4 and T3

  Cytomel – (generic name is liothyronine) – A manmade T3 hormone

There are many other brands of thyroid medications, however the above represents the majority of medications.

- Brooke Lounsbury, RN

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

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Two Tests to Assess Thyroid Function

Nearly 5 out of every 100 Americans ages 12 years and older have hypothyroidism, and about 1 out of every 100 have hyperthyroidism. Every year about 12,000 men and 33,000 women are diagnosed with thyroid cancer, and about 900 men and 1,000 women die from the disease. Thyroid diseases can have major, lasting effects on health if left untreated. Thyroid diseases are easily detected and effectively treated with the help of thyroid function tests. The following two tests are used to assess thyroid function. If these lab results come back abnormal your care provider will order more tests, some lab, ultrasound, biopsy, and others.

The most frequently used laboratory tests to assess baseline thyroid function in the U.S. are thyroid stimulating hormone (TSH) and free thyroxine.

TSH (Thyroid stimulating hormone)

TSH is the hormone produced by the pituitary gland that stimulates the thyroid gland to produce more thyroid hormone.

A normal TSH result, which is a blood test, falls between 0.4 and 4.0 milliunits per liter (mU/L), according to the American Thyroid Association. Ranges between laboratories will vary with the upper limit generally being between 4 to 5.

Higher levels of TSH can be indicative of:

  • Hypothyroid (low thyroid)- The most common form of hypothyroidism is Hashimoto’s thyroiditis, an autoimmune condition. Other hypothyroid conditions can be brought on by medications, thyroid cancer, and iodine deficiency to name a few.
  • Stress, such as exposure to cold, emotional stress, not sleeping well, hospitalization and any other types of stress. These all can raise cortisol levels, which in turn can cause a temporary high TSH level.

Lower Levels of TSH can be indicative of:

  • This is also known as an overactive thyroid. If a person’s thyroid gland is secreting levels of hormones that are too high, the pituitary gland produces less TSH.
  • A variety of conditions lead to hyperthyroidism, including Graves’ disease and thyroid nodules.
  • Pituitary gland tumor can stimulate the pituitary gland to release too much thyroid stimulating hormone

Thyroxine (T4)

Thyroxine, also known as T4, is the major type of hormone your thyroid releases. Too much or too little T4 can indicate thyroid disease.

Thyroxine (T4) is found in two forms:

  1. Bound T4: This form attaches to proteins, which prevents it from entering your body’s tissues.
  2. Free T4: This form “freely” enters your body’s tissues where it’s needed. The normal range for free T 4 in adults is 0.8 to 1.8 nanograms per deciliter (ng/dL)

There are a few different tests that measure T4 levels. A blood test that measures both free and bound T4 is called a total T4 test. Another test measures just free T4. Healthcare providers most often use a free T4 test to assess thyroid function because it’s more accurate than a total T4 test.

In conclusion, information from the TSH and free T4 tests help your cre provider assess if your thyroid gland is functioning properly. The thyroid gland is a complex gland, and there are many factors your care provider takes into consideration before making a diagnosis.

Next posts will delve into specific thyroid diseases and associated tests, starting with the most common form of hypothyroid- Hashimotos thyroiditis.

- Brooke Lounsbury

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

Keeping you informed and safe.

How Prepared are You for a Modern-Day Carrington Event?

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Fall travel abroad offers an opportunity for cooler weather, more affordable airfares, and less crowded venues. This is an ideal time to head to distant continents and enjoy fall festivals and activities this time of year before winter sets in. Whether hiking in the...

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Thyroid Gland Overview

The process which the body manufactures, and processes thyroid hormones is very complex. The following is an overview of the thyroid glands anatomy, function, hormones, and nutrients needed for proper function of the thyroid gland. Given this is a very complex gland, take your time reading and going through the video links.

Next post we will delve into thyroid tests and thyroid dysfunction- specifically low and high thyroid.

Thyroid gland and its function

  • Anatomy of the thyroid gland
  • Function of the thyroid gland
  • Hormones produced by the thyroid gland
  • Nutrients needed for proper functioning of the thyroid gland

Anatomy of the thyroid gland:

Every cell in the body has thyroid hormone receptors. These receptors control transcription and effect gene expression.

The thyroid gland is one of the largest endocrine glands and consists of two connected lobes. It is found in the neck, below the thyroid cartilage which forms the laryngeal prominence, or “Adam’s apple”. It is a butterfly-shaped organ and is composed of two cone-like lobes or wings, lobus dexter (right lobe) and lobus sinister (left lobe), connected via the isthmus. The thyroid is one of the larger endocrine glands, weighing 2-3 grams in neonates and 18-60 grams in adults, and is increased in pregnancy. The thyroid gland is covered by a thin fibrous sheath, composed of an internal and external layer. The thyroid tissue itself consists of a lot of small individual lobules joined together by thin sheaths of connective tissue. These lobules contain a great number of small vesicles, called follicles, which store thyroid hormones in the form of little droplets. These spherical follicles selectively absorb iodine from the blood for production of thyroid hormones and for storage of iodine in thyroglobulin (a protein present in the thyroid gland, from which thyroid hormones are synthesized). Thyroglobulin is also called colloid. Twenty-five percent of the body’s iodide ions are in the thyroid gland. Inside the follicles, in a region called the follicular lumen, colloid serves as a reservoir of materials for thyroid hormone production and, to a lesser extent, acts as a reservoir for the hormones themselves. The follicles are surrounded by a single layer of thyroid epithelial cells, which secrete T3 and T4. T3, also called triiodothyronine and T4, also called thyroxin are thyroid hormones.

Function of the thyroid gland

The thyroid plays an important role in regulating the body’s metabolism and calcium balance.  T4 and T3 hormones stimulate every tissue in the body to produce proteins and increase the amount of oxygen used by cells. The harder the cells work, the harder the organs work. The calcitonin hormone calcitonin works together with the parathyroid hormone to regulate calcium levels in the body. Some of the organ systems thyroid hormones regulate are:

  • Respiratory system– regulation of respiratory rate and ventilatory response to hypercapnia and hypoxia
  • Renal (kidney)– glomerular filtration rate and blood flow to the kidneys
  • Cardiovascular– regulates heart rate, force of cardiac contractions, stroke volume, cardiac output, catecholamine receptors
  • Metabolism- regulates glucose absorption in the gastrointestinal track, regulates insulin receptors
  • Growth and tissue development– regulates growth and maturation of bones and teeth, also regulates growth and maturation of epidermis, hair follicles and nails. Regulates force and rate of skeletal muscle contractions.
  • Nervous system-thyroid hormones are critical for neuronal development, Enhances memory and alertness.

 

Hormones produced by the thyroid gland

Check out this video on thyroid gland synthesis

What are the thyroid hormones and what substances do they contain? The thyroid hormones T3 (triiodothyronine) and T4 (thyroxine) are made of an amino acid, tyrosine, and an iodine molecule. For the hormone to be synthesized it must complete the following steps:

  1. Tyrosine, an amino acid that is provided by thyroid epithelial cells and secreted into the lumen of the follicle by a large glycoprotein scaffold called thyroglobulin. Thyroglobulin, as noted above is also called colloid.
  2. Iodine (or more accurately iodide) is taken up from blood by

thyroid epithelial cells which has an outer plasma membrane called a sodium-iodide symporter, or more commonly known as an “iodine trap”. Once inside the cell, iodide is transported into the lumen of the follicle along with thyroglobulin.

 

3. The thyroid hormone requires an enzyme called thyroid peroxidase to join the tyrosine with the iodine. The tyrosine will receive either one or two iodine. The term T1 represents one tyrosine and one iodine molecule. T2 represents one tyrosine and two iodine molecules.                                   

4. These, meaning T1 and T2, further combine through the enzyme thyroid peroxidase (TPO) to make the final thyroid hormones: T1+T2=T3 and T2+T2=T4. The byproduct from both reactions is hydrogen peroxide.

5. The thyroid hormone is bound to thyroglobulin and is liberated by hydrolytic enzymes that digest thyroglobulin.

6. The thyroid hormone diffuses out of the lysosomes and into the blood where they bind to carrier proteins and are transported to target cells in the body.

In other words,

T1+T2=T3+ hydrogen peroxide, and

T2+T2=T4+ hydrogen peroxide

Note:

T3 is up to four times more biologically active than T4. Only twenty percent of the body’s T3 is made by the combination of the T1 and T2 molecules. The additional eighty percent is made by T4 losing an iodine molecule in a process carried out in the organs such as the liver.

How is thyroid hormone regulated?

Hormonal output from the thyroid is regulated by thyroid-stimulating hormone (TSH) produced by the anterior pituitary, which itself is regulated by thyrotropin-releasing hormone (TRH) produced by the hypothalamus in a negative feedback loop.

This is described as follows:

HYPOTHALMUS-Signaled by low thyroid hormones the hypothalamus releases TRH (thyrotropin releasing hormone) which stimulates the pituitary gland, *Illustration depicts both high and low thyroid hormone events.

 ANTERIOR PITUITARY GLAND– Releases TSH (thyroid stimulating hormone) into the bloodstream, which reaches the thyroid gland

 THYROID GLAND –TSH (Thyroid stimulating hormone) causes thyroid gland to release thyroid hormones (T4 and T3 )

When enough T4 and T3 are in the bloodstream it signals the hypothalamus to stop releasing TRH (thyrotropin releasing hormone)

Nutrients needed by the thyroid gland

For the thyroid gland to function properly it requires a supply of nutrients

Selenium– Selenium content in the thyroid is higher than any part of the body. It is  a naturally occurring  trace mineral found in our foods and soil. One of the challenges with obtaining selenium from our food sources is that the levels can vary dramatically. Brazil nuts are known to be a rich source of selenium, but their selenium content varies according to the region they are grown in. 

Selenium is converted into three types of selenoproteins or seleno-enzymes, both terms are interchangeable.  The three types of selenoproteins are:

  1. GPx (glutathione peroxidase) are antioxidants and best known of the selenoproteins
  2. TRx- (thioredoxin reductases) are involved in cell growth and structure
  3. Dis (iodothyronine deiodinases) are involved in the conversion of T4 to T3 and other metabolic functions.

A selenium deficiency along with an iodine deficiency is implicated in goiters.

Iodine- Iodine is an essential element that is also needed from our environment. It is one of the building blocks of the thyroid molecule. For the body to be able to utilize iodine, it must be converted to iodide. This is accomplished through the thyroid peroxidase (TPO) reaction. Once this occurs, the free iodine joins with tyrosine to make the thyroid molecule, with hydrogen peroxide as the byproduct.

The group of molecules called the halogens; fluorine, bromine and chlorine mimic iodine and attach to tyrosine thereby rendering the tyrosine molecule useless. This means that your body is not getting the T4 or T3 it needs.  Sources of iodine include kelp, sea vegetables, cow’s milk, eggs, tuna, and navy beans. There are several over the counter iodine supplements. Caution should be exercised when using supplemental iodine. When there is an excess of iodine along with a deficiency of selenium, an autoimmune condition called Hashimotos thyroiditis may occur.

Tyrosine– Tyrosine is a nonessential amino acid the body makes from another amino acid called phenylalanine. It combines with iodine to form thyroid hormones. Tyrosine is also the precursor to neurotransmitters dopamine, epinephrine and norepinephrine. It is rare to have a deficiency in tyrosine and supplements are usually not recommended. Dietary sources of tyrosine are chicken, turkey, fish, peanuts, almonds, avocados, bananas, milk, cheese, yogurt, cottage cheese, lima beans, pumpkin seeds, and sesame seeds.

Zinc– Zinc is required to transform the inactive thyroid hormone T4 into the active form T3.  It plays an important role in immune function, wound healing, blood clotting, reproduction, growth and smell. Zinc supplementation should be approached carefully. If too much zinc is taken, a copper and iron deficiency can result. Also, taking too much zinc intake can contribute to hyperthyroidism and copper deficiency. Foods rich in zinc are raw pumpkin seeds, oysters, wheat germ, and lamb.

Iron (Ferritin) – Iron requires a high stomach acid for transport into the cells. Many people take iron tablets, and their iron levels stay the same due to low stomach acid.   Having low iron levels decreases deiodinase activity. It slows down the conversion of T4 to T3.  Insufficient iron levels may affect thyroid hormone synthesis by reducing the activity of the enzyme thyroid peroxidase (TPO) which is dependent on iron.  Thyroid peroxidase (TPO) brings about the chemical reactions of adding iodine to tyrosine (amino acid), which then produces T4 and T3. Insufficient iron levels alter and reduce the conversion of T4 to T3. Low iron levels can also increase circulating concentrations of TSH (thyroid stimulating hormone).

Apple cider vinegar or Betaine, a supplement which enhances stomach acidity, promotes protein breakdown and iron absorption.  The most bioavailable form of iron is called heme and is found in liver and meats

- Brooke Lounsbury

Medical Content Writer

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