Stings in a Disaster: The Antibiotic You Don’t Need and the Epinephrine You Do

Stings in a Disaster: The Antibiotic You Don’t Need and the Epinephrine You Do

Animals in a Disaster Series: Part 2 of 2
By the Jase Medical Team

The sting happens quickly.

Maybe you’re clearing branches after a storm. Maybe you’re walking through a flooded yard. Maybe you’ve returned home after an evacuation and disturbed insects that have moved into places they normally wouldn’t be.

By the next day, the sting looks worse.

The area is red. Hot. Swollen. Tender.

And the natural question is:

Is this infected?

Usually, it isn’t.

That’s one of the important differences between the bites we covered in Part 1 and insect stings.

Most stings look worse on day two than they did on day one—and that’s often the reaction doing exactly what it’s supposed to do.

A Sting Can Get Bigger Before It Gets Better

A typical insect sting can cause pain, redness, itching, and swelling around the site.

Sometimes that reaction stays small.

Other times, the swelling becomes surprisingly large. A sting on the hand might leave much of the hand swollen. A sting on the forearm might produce redness and swelling extending well beyond the tiny spot where the insect actually stung you.

These large local reactions can look dramatic.

They often increase over the first 24 to 48 hours before gradually improving over the following several days.

That timeline matters.

If you wake up the morning after a sting and the area looks considerably puffier than it did the night before, worsening appearance alone doesn’t automatically mean the sting has become infected.

Your immune system is reacting to venom introduced by the sting, and that inflammatory response can produce many of the same things people associate with infection: redness, warmth, swelling, and tenderness.

It’s one reason reaching for an antibiotic based solely on appearance can send you in the wrong direction.

Fire Ant Stings Look Especially Suspicious

After flooding, fire ants deserve special attention.

Fire ants can survive flood conditions by joining together into floating rafts, which means people working, walking, or cleaning up around floodwater can encounter them in unexpected places.

And their stings can produce something that looks particularly concerning:

small, white pustules.

If you’ve been taught that pus means infection, it’s understandable to look at those bumps and think something has gone wrong.

But the characteristic pustules that develop after fire ant stings are generally sterile. They’re part of the body’s reaction to the sting—not proof that bacteria have infected the skin.

So don’t pop or lance them.

Breaking the skin creates an opening for bacteria and can turn a sterile reaction into the infection you were trying to avoid.

Keep the area clean and let the pustules heal.

So When Should a Sting Concern You?

Most insect stings are uncomfortable rather than dangerous.

Redness and swelling around the sting—even significant swelling—can be part of a normal local reaction.

The situation changes when the reaction is no longer staying local.

There are a few signs we want you to remember:

Trouble breathing.

Swelling of the face, tongue, or throat.

Faintness, collapse, or feeling like you may pass out.

Symptoms affecting two different parts of the body at the same time.

That last one can be especially useful because anaphylaxis doesn’t always look like the version people expect.

For example, hives plus vomiting after a sting involve two different body systems. So do skin symptoms plus difficulty breathing.

If you’re having signs of a severe allergic reaction after a sting, call 911 immediately.

If you have been prescribed epinephrine for allergic emergencies, follow the emergency plan your clinician has given you. Epinephrine is the first-line treatment for anaphylaxis; antihistamines are not a substitute for it.

Don’t Wait for a Rash to Decide It’s Serious

Another misconception is that a severe allergic reaction has to come with obvious hives.

It doesn’t.

Trouble breathing, throat or facial swelling, faintness, collapse, or other signs of a systemic reaction after a sting warrant emergency attention even if your skin looks normal.

That’s why we don’t want you trying to decide whether a reaction “looks allergic enough.”

Look at what is happening throughout the body.

Local swelling around the sting is one thing. Symptoms involving breathing, circulation, or multiple body systems are another.

The Antibiotic Reflex Can Point You in the Wrong Direction

After a disaster, medical resources may be limited.

That makes it even more important to distinguish between something that looks infected and something that actually needs evaluation for infection.

A swollen, hot arm the day after a sting can be an inflammatory reaction.

Fire ant pustules can be sterile.

Neither automatically calls for an antibiotic.

And the other side of that distinction matters just as much: if someone is developing anaphylaxis, focusing on whether the sting might be infected misses the much more urgent problem.

That’s why appropriate medical preparation isn’t simply having more medication available.

It’s understanding which problem you’re actually dealing with.

Three Things to Remember After a Sting

You don’t need to memorize every insect or every possible reaction.

Remember these three things:

1. A normal sting reaction may look worse on day two.
Redness, warmth, swelling, itching, and tenderness can increase over the first 24 to 48 hours before gradually settling.

2. Fire ant pustules are supposed to look like that.
They’re typically sterile. Keep them clean and don’t pop or lance them.

3. Know the emergency signs.
Trouble breathing, swelling of the face or throat, faintness or collapse, or symptoms affecting two different parts of the body at once mean it’s time to call 911.

At Jase Medical, we’re a family team of medical doctors, PAs, and pharmacists focused on appropriate medical preparation: helping people understand the medical decisions that become harder when normal systems are disrupted.

We’re not a replacement for primary care or emergency medicine.

We’re interested in the grey space—the days after the storm when the clinic may be two hours away and knowing whether you’re looking at an expected reaction or an emergency suddenly matters a lot more.

Because after an insect sting, the reaction that looks infected often isn’t—and the reaction you can’t afford to miss isn’t an infection at all.


The Jase Medical Team is a family team of medical doctors, PAs, and pharmacists focused on appropriate medical preparation: clinically grounded readiness that complements, rather than replaces, the healthcare professionals you already trust.

This article was prepared by the Jase Medical content team for informational purposes only and does not constitute medical advice. Prescription requirements, emergency dispensing rules, insurance coverage, and controlled-substance regulations vary by medication, jurisdiction, and individual circumstances. Consult a licensed healthcare provider or pharmacist regarding your specific medications.

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For Clinicians | Animal Sting Reactions

For Clinicians | Animal Sting Reactions: Large Local Reaction vs Cellulitis, and When It’s Anaphylaxis

By Dr. Jamie Wilkey, PharmD, Director of Clinical Education
Medically reviewed and edited by Kristen Carpenter, PA-C

This is part two of our Animals + Disaster series. Part one was all about which bites actually need antibiotics. Today we are talking about stings. And stings get a sharper answer (gotta love that pun, right!): almost none of them. The drug that matters in stings isn’t an antibiotic at all. Today we’re sorting all of this out, plus what fire ant pustules are doing and the two stings that need something other than an antibiotic.

What a sting does to the body

A sting is venom, injected on purpose, by an animal defending itself. A bite is a wound with mouth bacteria in it. A sting inoculates almost nothing, so infection isn’t really that likely.

Almost everything that stings you is female because stingers are modified ovipositors. The 3 bugs that are most likely to sting you in the US are honeybees and bumblebees, the vespids (yellowjackets, hornets and paper wasps), and imported fire ants. Honeybees leave the stinger behind still pumping venom, so get it out fast. Speed is what matters and technique doesn’t. ¹ Vespids keep theirs and can sting over and over, which is how one disturbed nest becomes a multiple-sting patient. Fire ants bite to hold on, then pivot and sting in an arc, and that’s where the ring of pustules comes from. ²

Bee and vespid venom is mostly protein, and protein is what IgE recognizes, so those are the stings that turn allergic. Fire ant venom doesn’t have much protein and is mostly piperidine alkaloids which are directly cytotoxic. That’s the pustule, and it’s why no Rx you prescribe changes it. ²

So what you’re looking at comes down to which insect, how many stings, and whether that patient has already made IgE. Scorpions and spiders aren’t going to be covered today (hang tight for that article coming up soon!), and scorpion envenomation is neurotoxic rather than allergic anyway. 

Is a hot, swollen sting site cellulitis?

Usually not. The clock tells you more than the exam does. A large local reaction is a late-phase IgE response, not an infection. A typical sting will progress normally as swelling over 10 cm that’s still there past 24 hours,³ peaking somewhere in that 24 to 48 hour window, then taking 3 to 10 days to fully settle.⁴ Patients will tell you their whole arm is swollen, and they’re often right. Cellulitis runs on a different clock. It shows up later, and instead of peaking and receding it keeps spreading past the sting site. So check out which direction the site has been moving, not how angry it looks on the day you see it. A site still spreading after 48 hours is the one to treat.

You’re probably wondering how an anaphylactic reaction plays in here, and whether it relates to these exaggerated sting sites. They might relate a little. The guideline puts the risk of a systemic reaction under 10%, and anaphylaxis under 5%. It also says these patients usually just get another big local reaction.⁴ So the swollen arm by itself isn’t what makes you refer or write for epinephrine. A systemic reaction is.

Fire ant pustules are supposed to look like that

Leave them alone. That’s the whole intervention. Easy, huh!?

Fire ants create their own community raft on floodwater, with thousands locked together, and they sting on contact when somebody wades into one.⁵ So stings climb after heavy rain and flooding across the Southeast and Gulf. Dozens of stings on the feet and ankles, in rings, is fire ants and nothing else.⁶ 

24 to 48 hours post-sting the sting sites become sterile pustules. ² They really are sterile! They look exactly like infection and nothing reverses them, because the alkaloid already killed the cells. ² The skin over a pustule is protecting the tissue underneath. Lancing one creates a wound that may need an antibiotic.  Therefore, just good ‘ol soap and water plus an antibiotic cream if a pustule opens on its own. ² Fire ant anaphylaxis does happen, but is pretty uncommon. Serious systemic reactions run around 2% of fire ant stings in people who seek care. ² 

When is a sting an emergency, and how long do you watch?

There’s really only one sting emergency, and it’s anaphylaxis. You recognize it one of two ways: either two+ organ systems are involved, or the blood pressure drops (a systolic < 90 in an adult or a fall of more than 30% from their own baseline). Hives plus vomiting counts, and so does hives plus wheezing. A drop in blood pressure after a sting is enough on its own, without a second system getting involved at all. ⁷

When you see these symptoms give epinephrine. Must be epinephrine! An antihistamine and a steroid aren’t a substitute here and they don’t keep the reaction from coming back a few hours later, which is the thing we all hope they’ll do. ⁷ 

How long do you watch? We all learned 4 to 6 hours for everybody. Well, the 2023 practice parameter cut that down. If the reaction wasn’t severe, one hour with no symptoms after it resolves is enough, because nearly every biphasic reaction has declared itself by then. ⁷ Only a severe reaction, or one that took more than one dose, needs longer.

And just keep in mind a second epinephrine dose may be needed. In a 2021 systematic review, 17% of venom-triggered reactions needed one when a health care professional was there to give it.⁸ That’s more than most of us would guess, so don’t discount it.

When it’s the venom, not the allergy

A patient with 50 or more stings is a different problem entirely. There’s enough venom on board at that point to do direct damage, so what you’re watching for is rhabdomyolysis, acute kidney injury and hemolysis rather than an allergic reaction.⁹ Tolerance runs about 22 stings per kilo, which means roughly 500 can kill a child.¹⁰ Management of being a human sting pin cushion is aggressive fluids with an eye on urine output, and plenty of people add bicarbonate, though it has never been shown to beat saline alone.¹²  Either way it needs a hospital and not an autoinjector. All of it comes from case reports, though. There’s no guideline here.

The referral almost nobody makes

Anyone who has had a systemic reaction to a sting should be referred for venom immunotherapy. Untreated, about 40% of those patients have another systemic reaction the next time they’re stung. On immunotherapy it’s under 3%. ¹¹ Patients know this as allergy shots for bee stings, and that’s the phrase to use at the counter, because “venom immunotherapy” means nothing to them. After a disaster sting the referral almost never gets made, and it’s the only thing on this list that changes what the next sting does to them.

Where this fits

Nearly everything in this article is a decision rather than a prescription. Is the arm swelling or spreading? Is the pustule intact or opened? Those calls are all or none right now. Either a patient reaches a clinician who reads the clock, or they’re home staring at a hot red arm with a search bar and a leftover antibiotic.

Jase works the layer in between, and for stings that mostly isn’t a drug. It’s the thinking done in advance: which reaction is expected, which one is spreading, and which one means the epinephrine comes out. Where a prescription is part of it, a licensed provider reviews the request and writes it, for emergency use only and after first trying to reach a qualified provider. That’s what we mean by appropriate medical preparation, and it’s in no way a replacement for primary care. It’s for the days primary care isn’t reachable.

Part one of this series was about bites, and how few of them actually need an antibiotic. And as you’ll see in part two, stings need one even less often. We’ll keep publishing how we make these calls for appropriate medical preparation.

The bottom line

Antibiotics really don’t help with stings. The hot swollen arm that looks infected almost never is, and the sting that actually needs a drug needs epinephrine.

So read the clock instead of the redness. Leave the pustules alone from those fire ants. When two systems are involved or the pressure drops, give epinephrine and watch the hour. And when a patient has already had a systemic reaction, make the referral, because it’s the only thing you’ll do that changes what the next sting does.


Sources

  1. Visscher PK, Vetter RS, Camazine S. Removing bee stings. Lancet. 1996. PMID 8709689.
    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(96)01367-0/abstract
  2. Kruse B, Anderson J, Simon LV. Fire Ant Bites. StatPearls. Treasure Island (FL): StatPearls Publishing. Updated August 7, 2023. Venom is 95% water-insoluble alkaloid with a 5% aqueous protein fraction. Vesicles form within 4 hours and become sterile pustules by 24 hours. Serious systemic reactions occur in about 2% of fire ant stings among patients who seek care.
    https://www.ncbi.nlm.nih.gov/books/NBK470576/
  3. Tripolt P, Arzt-Gradwohl L, Čerpes U, Laipold K, Binder B, Sturm GJ. Large local reactions and systemic reactions to insect stings: similarities and differences. PLoS One. 2020;15(4):e0231747. Large local reaction defined as swelling exceeding 10 cm lasting more than 24 hours. Median duration 7 days, range 1 to 21 days, in 310 patients.
    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231747
  4. Golden DBK, Demain J, Freeman T, et al. Stinging insect hypersensitivity: a practice parameter update 2016. Ann Allergy Asthma Immunol. 2017;118(1):28-54. Large local reactions increase in size for 24 to 48 hours, exceed 10 cm contiguous to the sting site, and take 3 to 10 days to resolve. Patients with large local reactions have less than 10% chance of a systemic reaction and less than 5% chance of anaphylaxis, and usually have large local reactions again on subsequent stings.
    https://www.aaaai.org/Aaaai/media/Media-Library-PDFs/Allergist%20Resources/Statements%20and%20Practice%20Parameters/Stinging-insect-hypersensitivity-2016.pdf
  5. NIOSH. Hurricane and Flood Key Messages for Employers, Workers, and Volunteers, Third Edition. Atlanta, GA: US Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2025-106; 2025. Fire ants “can cling together and float along in floodwaters,” sting aggressively when disturbed, and red bumps “within a day or two become white fluid-filled pustules.”
    https://www.cdc.gov/niosh/docs/2025-106/pdfs/2025-106.pdf
  6. Diaz JH. The impact of hurricanes and flooding disasters on hymenopterid-inflicted injuries. Am J Disaster Med. 2007;2(5):257-269. PMID 18491841.
    https://doi.org/10.5055/ajdm.2007.0034
  7. Golden DBK, Wang J, Waserman S, et al. Anaphylaxis: a 2023 practice parameter update. Ann Allergy Asthma Immunol. 2024;132(2):124-176. PMID 38108678. Reduced blood pressure defined as systolic below 90 mm Hg in adults or a decrease greater than 30% from that person’s baseline. Biphasic anaphylaxis is unlikely when the reaction is not severe and the patient remains symptom-free for one hour after resolution, a 95% negative predictive value (95% CI 90.9%-97.3%), and is likelier with increasing severity and in patients given more than one epinephrine dose.
    https://www.aaaai.org/Aaaai/media/Media-Library-PDFs/Allergist%20Resources/Statements%20and%20Practice%20Parameters/Anaphylaxis-Practice-Paramaters-2023.pdf
  8. Patel N, Chong KW, Yip AYG, et al. Use of multiple epinephrine doses in anaphylaxis: a systematic review and meta-analysis. J Allergy Clin Immunol. 2021. PMID 33862009. Across 86 studies and 36,557 events, 7.7% of anaphylaxis events from any cause required more than one dose. Among venom-induced reactions in which a health care professional administered the subsequent dose, 17.1% (95% CI 11.3-25.0).
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588837/
  9. Osman UMA, Turfan S, Mohamud MFY. Multi-organ dysfunction due to envenoming syndrome following a massive bee attack: a fatal case study and comprehensive literature review. Int Med Case Rep J. 2024;17:353-357. PMID 38646457. More than 50 stings is categorized as massive envenomation, with rhabdomyolysis, acute kidney injury, hemolysis, DIC and myocardial injury described. Case report with literature review.
    https://doi.org/10.2147/IMCRJ.S456777
  10. Insect Stings. Merck Manual Professional Version. The average unsensitized person tolerates 22 stings/kg body weight, so an adult can withstand more than 1,000 stings whereas 500 stings can kill a child.
    https://www.merckmanuals.com/professional/injuries-poisoning/bites-and-stings/insect-stings
  11. Boyle RJ, Elremeli M, Hockenhull J, et al. Venom immunotherapy for preventing allergic reactions to insect stings. Cochrane Database Syst Rev. 2012;CD008838. PMID 23076950. Subsequent systemic sting reaction in 3 of 113 treated patients (2.7%) versus 37 of 93 untreated (39.8%). Risk ratio 0.10, 95% CI 0.03-0.28.
    https://doi.org/10.1002/14651858.CD008838.pub2

 

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Bites and Scratches in a Disaster: Which Ones Need Antibiotics

Bites and Scratches in a Disaster: Which Ones Need Antibiotics

Animals in a Disaster Series: Part 1 of 2
By the Jase Medical Team

Three days after the storm, the animal injuries start showing up.

A cat got loose during the evacuation and bit someone’s hand when they tried to grab it. A neighbor’s dog, frightened by the noise and crowded shelter, snapped when someone cornered it. Someone else scraped their palm while clearing debris from standing water.

When normal healthcare is available, the next steps are fairly straightforward: clean the wound, decide whether it needs additional treatment, and watch it closely.

After a disaster, that last part can get complicated.

The clinic may be closed. Roads may be blocked. Cell service may be unreliable. Getting a wound checked again tomorrow or the next day may not be as easy as it normally would be.

That’s why a bite is one of those injuries where what you do in the first hour can matter more than what you have in the medicine cabinet.

And the first step isn’t an antibiotic.

It’s water.

First: Wash the Bite or Scratch Thoroughly

If an animal bites or scratches you, clean the wound right away.

Use soap and plenty of running water. If you’re dealing with disrupted utilities after a disaster, use clean, potable water.

Don’t give it a quick rinse and move on. Thoroughly washing the area helps physically remove saliva, dirt, and bacteria introduced into the wound.

This matters especially with animal bites because what looks small on the surface may not tell you much about what happened underneath.

Cat bites are a good example. Their teeth can create narrow punctures that push bacteria deeper into tissue even when the wound itself doesn’t look dramatic.

So whether you’re at home, evacuating, or staying in a shelter:

Wash first. Wash thoroughly. Wash right away.

Which Animal Bites Need Medical Attention?

Not every scratch requires an antibiotic.

But certain wounds deserve a lower threshold for getting medical care—especially when you know it may be difficult to have the wound rechecked later.

Pay particular attention to:

  • Bites to the hand
  • Deep puncture wounds
  • Wounds near a joint
  • Wounds exposed to floodwater
  • Increasing redness, warmth, swelling, or pain
  • Pus or cloudy drainage
  • Redness spreading away from the wound
  • Red streaking up an arm or leg
  • Fever or feeling increasingly unwell

If those signs appear, the best next step isn’t guessing which medication in your emergency supplies might work.

It’s reaching a qualified medical professional as soon as you can.

That’s especially important after a disaster, when the ability to simply “check it again in 48 hours” may not exist.

Why the Hand Deserves Extra Attention

A bite on your hand may look relatively minor.

Its location makes it more concerning.

Your hands pack tendons, joints, bones, and other important structures into a small space. A puncture that introduces bacteria into those deeper structures can become more complicated than a similar-looking wound elsewhere.

That doesn’t mean every hand bite is an emergency.

It does mean a bite to the hand is worth getting evaluated rather than assuming a small wound means a small problem.

And if you know access to healthcare may become more difficult over the next several days, mention that when you speak with the clinician evaluating you.

The wound hasn’t necessarily changed.

The safety net has.

Floodwater Changes the Wound

Maybe an animal wasn’t involved at all.

You’re clearing branches after a hurricane, catch your hand on a piece of debris, and the open wound goes straight into standing floodwater.

That’s useful information for a clinician.

Floodwater can contain sewage, bacteria, chemicals, debris, and other contaminants. A wound exposed to it isn’t necessarily the same clinical situation as a clean cut that happened inside your house.

If you’re evaluated, tell the clinician specifically that the wound was exposed to floodwater.

Don’t just say, “I cut my hand.”

The environment surrounding the injury matters.

Every Animal Bite Comes With Two More Questions

Whether or not the wound eventually needs antibiotics, there are two other questions you shouldn’t forget:

What about rabies?

What about tetanus?

1. Does This Animal Raise a Rabies Concern?

Rabies decisions depend heavily on what animal caused the exposure and whether that animal can be located.

That’s why, after cleaning the wound, write down what you know.

Was it your neighbor’s dog? A stray cat? A raccoon? A fox? Was there a bat in the room? Can the animal be found again?

Don’t try to determine on your own whether you need rabies post-exposure treatment. Contact a healthcare professional or public health authority who can evaluate the specific exposure.

And here’s an especially important point after a disaster:

Don’t assume you’re “too late” to ask about rabies because several days have passed.

If roads were blocked and you couldn’t reach care immediately, still bring it up when you can. Rabies post-exposure decisions should be made with medical or public health professionals rather than abandoned because you think you’ve missed a window.

2. Are You Up to Date on Tetanus?

Tetanus is another reason the circumstances of the wound matter.

After a storm, people are moving branches, handling damaged metal, clearing wreckage, walking through debris, and sustaining punctures and dirty wounds they wouldn’t normally encounter.

If you have a bite, puncture, or contaminated wound, tell the clinician when you last received a tetanus-containing vaccine—or tell them if you don’t know.

Don’t assume the risk comes specifically from floodwater or from something being “rusty.”

The wound itself and how it happened are what matter.

Don’t Let the Medicine Cabinet Make the Decision

It can be tempting after a disaster to look at an animal bite, see an antibiotic in your emergency supplies, and think:

I have this. Maybe I should take it just in case.

That’s not the decision we want you making on your own.

Whether a bite needs antibiotics depends on factors including where it is, how deep it is, whether infection is already developing, your health history, and what contaminated the wound.

And antibiotics aren’t the only decision.

A wound may need professional cleaning or evaluation of deeper structures. A bite may raise a rabies question. A dirty wound may change the tetanus conversation.

Having medication available doesn’t answer any of those questions.

Clinical judgment does.

The First-Hour Plan Is Simple

You don’t need to memorize every organism associated with animal bites or every guideline for antibiotic prophylaxis.

Remember this instead:

Clean it. Look at where it is and how deep it went. Ask about rabies. Ask about tetanus.

And if it’s a hand bite, a deep puncture, a wound that entered floodwater, or a wound developing spreading redness, drainage, fever, or increasing pain, make getting medical guidance a priority.

At Jase Medical, we’re a family team of medical doctors, PAs, and pharmacists focused on appropriate medical preparation: helping people think through the medical layer of emergencies before normal systems become difficult to reach.

We’re not a replacement for primary care.

We’re the clinicians who would rather you know what matters before the road is closed, the clinic is unavailable, and you’re staring at a wound wondering whether it can wait.

Because with an animal bite, what you do in the first hour may matter more than what you have in the cabinet.

Next in the Animals in a Disaster Series: Stings After a Disaster: When It’s an Allergic Reaction—and When You Need Epinephrine.


This article was prepared by the Jase Medical content team for informational purposes only and does not constitute medical advice. Prescription requirements, emergency dispensing rules, insurance coverage, and controlled-substance regulations vary by medication, jurisdiction, and individual circumstances. Consult a licensed healthcare provider or pharmacist regarding your specific medications.

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For Clinicians | Bite and Scratch Wound Antibiotic Prophylaxis Without a 48-Hour Recheck

Bite and Scratch Wound Antibiotic Prophylaxis Without a 48-Hour Recheck

By Dr. Jamie Wilkey, PharmD, Director of Clinical Education 
Medically reviewed and edited by Kristen Carpenter, PA-C

September is National Preparedness Month, and at Jase we love this month. I’d like to focus today on something most preparedness aids skip: animals. This is part one of our two-part Animals + Disaster series. Part one covers the attacks, the bites and scratches from animals and how a delay of care can affect their treatment. And we will end the article with a rabies and TDAP refresher because no bite and scratch article would be complete without that part. Part two covers stings, which behave nothing like bites: the reaction that gets mistaken for an infection, and the one that actually needs epinephrine.

You already know how to manage a bite or a scratch. What makes them interesting in a disaster is the last line of the guideline, the one that says see them back in 48 hours. That initial check and/or recheck delay makes a big difference. Today we’re talking about how that decision changes when you have to make the whole call up front. This is decision support for you as a clinician, not a self-treatment guide for your patients.


The first 48 hours of a bite wound (for cats and dogs)

Let’s start with the fresh, ouchy animal bite wound itself. A cat bite is a narrow, deep puncture that seeds bacteria under the skin and closes over the top, which is why cat bites infect around 30% of the time against 2 – 25% for dog bites.¹ Cleaning the wound well is key here. Irrigate with a syringe or a high-pressure system, 1% to 5% povidone iodine in normal saline, or potable water when you’re out of hospital.¹ Then leave it open. Closure is for cosmetic wounds (mostly the face), and cat bites stay open regardless.¹ None of that really needs a clinic. What you lose without a clinic though is an expert eye’s second look.

Now onto the recheck. Forty-eight hours isn’t some arbitrary number. Bite infections declare early, cat bites typically inside 12 to 18 hours, showing up as erythema, induration, pain and purulent drainage.¹ Most of what’s going to turn has turned inside those first 48 hours. Observation doesn’t prevent infection. It catches it while it’s still small and still local. With a provider, that look is yours to catch early. Without one, someone in the household is doing it. 

When nobody sees it at all

In a real disaster most of these wounds never get a clinician right away, either. Which makes the brief you give patients ahead of time worth more than anything you’d do at the visit. It’s short.

Wash the wound right away and thoroughly, soap and running water, and potable water is fine when there’s nothing sterile.¹ ² Leave it open, don’t tape or butterfly it closed.¹ Write down what bit them and whether the animal can be found again, because that answer is the difference between observing a dog for 10 days and starting a rabies series. ³

Then give them a very, very specific watch list (not just, ‘if it gets worse, call me’): spreading redness, swelling, warmth, pus, or a red streak running up the limb.¹ Those signs can be muted in an immunocompromised patient.¹ Also fever and pain way out of proportion to what is expected. When Kristen (the article reviewer) is in clinic, she’s watching bites around joints (especially hands) way more carefully than soft tissue (osteomyelitis risk). Cat bites tend to declare within 12 to 18 hours, so the first day is the one to keep an eagle eye on it.¹

And be clear about what the trigger does. If the bite gets worse, the best move is reaching a clinician, however far or inconvenient that is, not resorting to medications on hand and guessing. 

Who gets antibiotics when you can’t see them again

Normally you give antibiotics after a bite to a short list of patients and watch everybody else. IDSA’s list: immunocompromised or asplenic, advanced liver disease, a bite area already swelling, a moderate to severe wound especially on the hand or face, or a wound that may have gone into periosteum or joint capsule. A three to five day course for this group.⁴ Everyone else gets cleaned up and watched.

If a recheck isn’t available in 48 hours add hand bites to the antibiotic list. It’s the one bite site (hey, that rhymes!) where prophylaxis is proven, cutting infection from 28% to 2%.⁵ ⁶ Past that, the list shouldn’t grow much. The studies never showed antibiotics help an ordinary dog or cat bite,⁵ ⁷ and every course spent on a small, clean one is a course that’s now gone when a bad, messy one shows up.

Amoxicillin-clavulanate is the first line treatment, 875/125 mg twice daily in adults ⁶ and 22.5 mg/kg twice daily in kids.⁸ If you don’t have it, then please know that cephalexin, dicloxacillin and erythromycin have inadequate activity against Pasteurella and should be avoided. ⁹ For penicillin allergy, adults get clindamycin 300 mg three times daily plus ciprofloxacin 500 mg twice daily, or doxycycline. Children get clindamycin 10 to 25 mg/kg divided every 6 to 8 hours plus TMP-SMX. Pregnant and penicillin-allergic, azithromycin 250 to 500 mg daily, watched closely, because the failure rate is high. ⁶

Scratches don’t follow the 48-hour rule

A fresh cat scratch mostly needs soap and water.² There’s no prophylaxis decision to make, because what goes wrong with a scratch takes longer than the 48 hour bite window.

Cat scratch disease (CSD or cat scratch fever) runs on a much longer schedule. A papule comes up at the scratch and sits there 1 to 3 weeks, and a swollen node upstream develops over 1 to 2 weeks.² The patient you see on day two has nothing to find because it hasn’t fully developed yet. What looks like a little scratch on day 2 can turn into a pretty impressive axillary node weeks later and by then they’ve forgotten all about that darn kitty.

Then it mostly handles itself. CSD resolves with supportive care in 90 to 95% of children, though resolving means 2 to 4 months of that node slowly going down.² Azithromycin shrinks the node faster without meaningfully shortening the illness, if you want it: 10 mg/kg on day 1 then 5 mg/kg days 2 through 5, adult max 500 then 250.² The patients who genuinely need treating are the immunocompromised, to keep it from going systemic.²

So the counseling right up front is going to be more helpful than an Rx. A lump may come up in a few weeks, it’s expected and totally normal, and it isn’t a reason to spend an antibiotic course you may need for something worse. One exception: a scratch from a fox or a raccoon is a rabies question. ¹⁰ Let’s get into that next!

Nobody is too late for rabies PEP

Now, this article would be wildly incomplete without bringing up rabies. The CDC says start PEP regardless of how long it’s been, as long as the patient isn’t already showing signs of rabies.¹¹ 

Rabies lives in bats, raccoons, skunks and foxes, at 35%, 29%, 17% and 8% of reported animal cases. ¹⁰ Of the ones that get close enough to expose somebody, about 10% of raccoons are rabid, and more than 20% of skunks and foxes are too. ¹⁰

Rodents and rabbits are the opposite story. Squirrels, chipmunks, rats, mice and their relatives are rarely infected and have never been known to give rabies to a person, so those bites almost never need PEP. ³ The exception is the groundhog, which accounted for about 92% of rabid rodents and lagomorphs reported from 2011 to 2020.¹² Even so, no human rabies death in the US has ever been traced to a rodent or a lagomorph (rabbit, etc).¹²

Before committing to a PEP series, ask whether the animal can be found. A healthy domestic dog, cat or ferret can be confined and observed for 10 days instead. ³ Especially when vaccine and HRIG are hard to reach, that’s the first question. 

Where this fits

In every scenario above, what the patient needed first was clinical decisions: 

  • is this the wound that gets treated?
  • is this the drug that covers Pasteurella?
  • is this the node that’s going to be fine on its own?
  • is this an animal that commonly carries rabies?

Right now that decision is all or nothing. Either they reach a clinician and get it made, or they’re alone with a wound, a hodgepodge medicine cabinet and an internet search.

Jase works on the narrow layer in between: the clinical thinking done ahead of time, by a licensed provider who reviews the request and writes the prescription, for a short list of predictable problems, for emergency use only and after first trying to reach a qualified provider. That’s what we mean by appropriate medical preparation. It’s in no way a replacement for primary care. It’s for the days when primary care isn’t reachable.

We’ll keep publishing how we draw these lines, including the ones we’re still arguing about, because this is grey space and clinicians should be the ones charting it.

The bottom line

When the recheck disappears, the wound hasn’t changed. The safety net did.

So clean it properly, treat IDSA’s short list and add the hand, and hold the line on everything else, because the course you don’t spend today is the one still available next week. Send them out knowing what a turning wound looks like, who to call when they see it, and that a node coming up three weeks later is usually nothing to spend a prescription on. And if rabies is on the table, nobody has missed the window.


Sources

  1. Indramohan G, Marietta M, Collier SA. Animal Bites. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Updated July 5, 2026. https://www.ncbi.nlm.nih.gov/books/NBK430852/
  2. Sabir S, Daley SF, Huang B. Cat Scratch Disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Updated December 13, 2025. https://www.ncbi.nlm.nih.gov/books/NBK482139/
  3. Centers for Disease Control and Prevention. Human Rabies Prevention, United States, 2008: Recommendations of the Advisory Committee on Immunization Practices. MMWR Recommendations and Reports. 2008;57(RR-3). https://www.cdc.gov/mmwr/pdf/rr/rr57e507.pdf
  4. Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJC, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases. 2014;59(2):e10-e52. https://academic.oup.com/cid/article/59/2/e10/2895845
  5. Medeiros I, Saconato H. Antibiotic prophylaxis for mammalian bites. Cochrane Database of Systematic Reviews. 2001;(2):CD001738. https://www.cochrane.org/evidence/CD001738_antibiotics-reducing-rate-infection-after-bites-mammals-such-humans
  6. Ellis R, Ellis C. Dog and Cat Bites. American Family Physician. 2014;90(4):239-243. https://www.aafp.org/pubs/afp/issues/2014/0815/p239.html
  7. Grillo R, Brozoski MA, Moreira SB, da Silva YS, Borba AM, Naclério-Homem MG. Antibiotic prophylaxis for animal inflicted maxillofacial injuries: a systematic review and meta-analysis. Frontiers of Oral and Maxillofacial Medicine. 2024. https://fomm.amegroups.org/article/view/80777/html
  8. Dannenberg MA, Herigon J. Wise Use of Antibiotics: Management Strategies for Common Animal Bites. The Link, Children’s Mercy Department of Evidence Based Practice. April 2025. https://www.childrensmercy.org/health-care-providers/refer-or-manage-a-patient/connect-with-childrens-mercy/newsletter-the-link/the-link-2025/the-link—april-2025/wise-use-of-antibiotics-management-strategies-for-common-animal-bites/
  9. Hasan J, Hug M. Pasteurella Multocida. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Updated May 16, 2023. https://www.ncbi.nlm.nih.gov/books/NBK557629/
  10. Centers for Disease Control and Prevention. Rabies in the United States: Protecting Public Health. https://www.cdc.gov/rabies/php/protecting-public-health/
  11. Centers for Disease Control and Prevention. Rabies Post-Exposure Prophylaxis: Clinical Care for Healthcare Providers. https://www.cdc.gov/rabies/hcp/clinical-care/post-exposure-prophylaxis.html 
  12. Rabies in Rodents and Lagomorphs in the USA, 2011-20. Journal of Wildlife Diseases. 2023;59(4):734-742. doi:10.7589/JWD-D-23-00036. https://bioone.org/journals/journal-of-wildlife-diseases/volume-59/issue-4/JWD-D-23-00036/RABIES-IN-RODENTS-AND-LAGOMORPHS-IN-THE-USA-201120/10.7589/JWD-D-23-00036.full

 

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Psychiatric Medications Need a Different Emergency Plan

Psychiatric Medications Need a Different Emergency Plan

Part 2 of a two-part series on medication readiness during a disruption

By the Jase Medical Team

In Part 1 of this series, we asked a question most people have never considered: If you suddenly couldn’t access your regular medications, which ones would be most important not to interrupt?

The takeaway was simple: your prescriptions aren’t interchangeable. Rather than trying to rank them yourself during an emergency, ask your healthcare team ahead of time which medications should receive the most urgent attention and add that information to your written medication list.

But there’s one category that doesn’t fit neatly into that ranking: psychiatric medications.

With certain psychiatric medications, losing access isn’t the only consideration. How treatment is resumed after an interruption can matter too. Others carry specific concerns if they’re stopped abruptly or if the conditions around you—such as illness, heat, or dehydration—change.

That means simply knowing where a psychiatric medication falls on your priority list may not be enough.

You need to know the plan for an interruption—and what happens afterward.

The Gap in Most Emergency Plans

Disaster planning tends to separate physical health and mental health into two different conversations.

Medication continuity guidance often focuses on chronic prescriptions people may need replaced after an evacuation, such as medications for heart disease, diabetes, thyroid conditions, and other ongoing medical needs. Mental health preparedness, meanwhile, tends to focus on what a disaster can do to someone’s emotional and psychological well-being: stress, anxiety, trauma, crisis support, and recovery.

Both matter. But there’s a patient who can fall directly between those two conversations: the person who was already taking a psychiatric medication before the disruption began.

Their emergency plan needs to account for that medication too.

Why Psychiatric Medications Need Their Own Plan

Psychiatric medications don’t all behave the same way, so this isn’t a medication-by-medication guide. But a few examples show why this category deserves more deliberate planning.

Clozapine is one of the clearest. An interruption isn’t only about missing the medication; how it is restarted can carry its own clinical considerations. Benzodiazepines present another concern: for someone who is physically dependent on one, abruptly stopping can cause serious withdrawal, including seizures or delirium. Lithium illustrates a different kind of problem, because dehydration and changes in fluid balance can increase the risk of toxicity even when someone hasn’t intentionally changed how they’re taking it.

These examples aren’t instructions for what to do with any particular medication. They’re the reason the instructions need to come from your own prescriber before an emergency happens.

The takeaway isn’t to memorize how each psychiatric medication behaves. It’s to understand that “I’ll just restart it when I get more” may not be an appropriate plan.

Ask Before Anything Happens

There is one useful preparedness question to bring to your psychiatrist, primary care provider, or other prescriber:

“If I can’t fill this medication for several days, what do you want me to do?”

You aren’t asking for permission to change your medication on your own or creating a DIY dosing plan. You’re asking your prescriber to tell you, in advance, what you should do if a disruption affects access.

Then write the answer somewhere you’ll actually find it.

Keep it with your current medication list, along with the medication name, dose, prescriber, pharmacy, allergies, and important treatment information. If a spouse, parent, adult child, or other trusted person helps with your healthcare, make sure they know where that information is too.

NAMI’s Portable Treatment Record is one resource designed to help individuals and families keep important mental health treatment information organized and accessible.

Make Sure the Information Can Leave With You

Having the plan written down only helps if you can access it when normal life is disrupted.

Research examining medication loss during disasters found that people who had prepared an emergency bag were 5.7 times more likely to evacuate with their medications than those who hadn’t.

For psychiatric medications, preparedness doesn’t mean accumulating extra prescriptions or trying to work around prescribing rules. Some medications in this category are controlled substances with specific legal and dispensing requirements.

The practical preparation is much simpler: keep the medications you currently have and the treatment information that goes with them organized so they’re ready to leave with you.

Your emergency bag shouldn’t just have a flashlight, charger, water, and insurance documents. Your medication plan needs a place in it too.

If Access Is Already Interrupted

If you’re already unable to access a psychiatric medication, don’t use a generic online guide to decide how to stop, restart, stretch, reduce, or otherwise change it.

Contact your prescriber or pharmacist for guidance specific to your medication and medical history. If your usual provider is unavailable, another healthcare professional may be able to help determine the appropriate next step.

The goal of preparing ahead isn’t to make these clinical decisions yourself. It’s to avoid having to figure out what your prescriber would want you to do while the pharmacy is closed, you’re away from home, or the rest of an emergency is already demanding your attention.

If you or someone you care for is experiencing a mental health crisis or needs immediate support in the United States, call or text 988.

The Emergency Plan Most People Never Write

There is nothing to buy for this part of medical preparedness.

There is simply a conversation to have while your next appointment is still just a normal appointment and your next refill is still just a normal refill.

Part 1 of this series was about knowing which of your medications needs your attention first if access is disrupted. For psychiatric medications, take that preparation one step further: know what your prescriber wants you to do if access is interrupted—and make sure that answer can travel with you.

Because the middle of an emergency is not the time to discover that stopping and restarting a medication may each require their own plan.

The Jase Medical Team is a family team of medical doctors, PAs, and pharmacists focused on appropriate medical preparation: clinically grounded readiness that complements, rather than replaces, primary care and the healthcare professionals you already trust.


This article was prepared by the Jase Medical content team for informational purposes only and does not constitute medical advice. Prescription requirements, emergency dispensing rules, insurance coverage, and controlled-substance regulations vary by medication, jurisdiction, and individual circumstances. Consult a licensed healthcare provider or pharmacist regarding your specific medications.

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Everyone should be empowered to care for themselves and their loved ones during the unexpected. Check out our recent lifesaving products today.

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For Clinicians | Animal Sting Reactions

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Psychiatric Medications Need a Different Emergency Plan

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Psychiatric Medications Need a Different Emergency Plan Part 2 of a two-part series on medication readiness during a disruption By the Jase Medical Team In Part 1 of this series, we asked a question most people have never considered: If you suddenly couldn't access...

read more

Join Our Newsletter

Our mission is to help you be more medically prepared. Join our newsletter and follow us on social media for health and safety tips each week!