For Clinicians | Off-Grid Health Care: A Guide to Medical Preparation When the System Fails (aka SHTF)

For Clinicians | Off-Grid Health Care

A Guide to Medical Preparation When the System Fails (aka SHTF)

By Dr. Jamie Wilkey, PharmD — Director of Clinical Strategy, Jase
Edited and approved by Kristen Carpenter, PA-C — Clinical Advisory Board Member

Your patient has already Googled “SHTF medical” at 11pm. They didn’t bring it up at the visit because they don’t think you’ll know what to say. They might be right.

They are not alone. Behind every shortage story (saline, Adderall, Ozempic, amoxicillin liquid, the two weeks of hurricane evacuations that emptied a region’s pharmacies), patients are running a quiet clinical question through their head: “What’s reasonable to have on hand,…… just in case?”
Most of us were never trained to answer it. Yet, when we hedge, the prepper internet doesn’t. It tells them to buy fish antibiotics and trust no one. Our silence on the subject isn’t helping our patients: it’s giving them only extremes to turn to for answers.

Today we’re talking about this question. The category is appropriate medical preparation, sized to the disruptions families actually face, not a doomsday-world-is-ending scenario.

The framework breaks into five modules: medication, trauma and wound care, water and sanitation, power and continuity, and household-specific layers. A sixth, capability, makes the rest work or not.


Medication: chronic supply, contingency supply

This is where preparation actually starts, and where the bulk of the work is. The hurricane Katrina chronic-disease data is dated but still the cleanest evidence we have on what happens when a region’s pharmacies go offline, settles the question of priority. Of medications dispensed to evacuees in San Antonio, 68% were for chronic disease. Cardiovascular alone was 39%. The federal stockpile supplied 9%. Retail pharmacies covered 73%¹.

What we don’t really recognize here is that the patient’s own medicine cabinet is the primary line. Federal caches and DMAT formularies are backstops, not plans.

So the first tier is the chronic supply, patient-owned. A 90+ day on-hand supply of every prescription the household can’t go without, paired with a written list any pharmacist can act on (drug, dose, prescriber, pharmacy). You might object that this isn’t preparation, it’s just well-managed primary care. Yep. That’s the point. The category isn’t separate from primary care. It’s primary care that takes evacuation, supply chain disruption, and Friday-night closures seriously. Ready.gov anchors a 3-day baseline kit². Disaster medicine literature pushes 30 to 90 days for chronic meds³. What actually holds up in a big disaster is closer to 90 days to have on hand.

The trickier prescriptions to navigate are controlled substances. Schedules III through V are workable. During a governor’s declaration, pharmacists in most states can dispense an emergency supply (typically up to 30 days) without a new prescription on file⁵. Coverage varies by state but typically includes medications like benzodiazepines, tramadol, and codeine combinations, the prescriptions most likely to surface in a sheltered population.

Schedule II is the cliff. Stimulants and most opioids. A declared disaster does not, by itself, authorize a Schedule II refill. That takes a fancy, specific DEA waiver, and the waivers are inconsistent. We don’t endorse stockpiling. We also don’t have a clean way to tell a patient on a Schedule II to save some each month, because clinically that’s the opposite of how these medications are supposed to be taken. There is a gap. They should just know ahead of time, and so should we, that navigating this one is inherently just going to be very tricky.

The second tier is the contingency supply. The prescription half: short-course antibiotics, antifungals, rescue inhalers, oral rehydration salts, basic wound care. The OTC half: acetaminophen, ibuprofen, diphenhydramine, loperamide, antacids, electrolyte tablets, meclizine, loratadine, bismuth subsalicylate. The clinical logic for the prescription half is the same one telehealth platforms already use for the same conditions, with the same prescribing patterns and the same evidence base. The only difference is timing. Same medications, same standards, prescribed before symptoms arrive instead of after.

This is the gap JaseCase is built to close: amoxicillin-clavulanate, azithromycin, ciprofloxacin, doxycycline, metronidazole, a methylprednisolone dosepak, ondansetron, triamcinolone topical, plus the OTC backbone.


Trauma: bleeding control, wound care, burns

The medication layer is what you have when the pharmacy is gone. The trauma layer is about what you do in the minutes before EMS can get there. Hemorrhage is the only category of injury where a layperson can credibly outperform “wait for the ambulance,” and that’s the core of this section.

Stop the Bleed has been around long enough that most clinicians know the program by name, but the kit itself doesn’t follow most patients home. The core list is short and CoTCCC-vetted: a CoTCCC-listed windlass tourniquet, hemostatic-impregnated gauze (kaolin-based is the canonical mechanism), a 4 to 6 inch pressure dressing, nitrile gloves, trauma shears, and a permanent marker for time-of-application⁶. Skill-retention data argue for refreshing training every 1 to 2 years⁷. The fact that a tourniquet is in the kit doesn’t mean a patient knows when to reach for one.

That set, plus a pair of vented chest seals, a space blanket for hypothermia prevention, and a casualty card, is what separates a real household IFAK from a box of band-aids. NPAs and needle decompression are training-dependent. They belong in the kit when a household member has been trained to use them, and they don’t when no one has.

Most calls to use the kit aren’t going to be trauma though. They’ll be wound care, and the Wilderness Medical Society’s 2014 austere wound care guidelines are the cleanest reference⁸. Irrigate with at least 1 liter of potable or disinfected water at pressure (a 30 to 60 mL syringe with an 18 gauge angiocath does the job). No additives in routine wounds. Close clean, low-tension wounds within 8 to 12 hours, up to 24 for the face, with adhesive closure strips or tissue adhesive. Sutures and staples belong in trained hands, not a kitchen. Pack contaminated wounds open and watch them. AAFP evidence is clear that plain white petrolatum is equivalent to triple antibiotic ointment for routine wound aftercare, with less contact dermatitis and less selection pressure on resistant flora⁹. The kit version: petrolatum, non-adherent dressings, gauze rolls, adhesive strips, tissue adhesive, sterile gloves. Teach the household what infection actually looks like: spreading erythema, streaking, purulence, fever, increasing pain.

Burns are the injury most under-prepared for, and the field guidance has changed. The American Burn Association and the 2025 Annals of Emergency Medicine literature now support 20 minutes of cool running water (not ice, not butter) within 3 hours of injury, with measurably better outcomes¹⁰. Cover with a non-adherent dressing or plastic cling wrap. Hydrogel burn dressings are a field-acceptable third option per ABA, distinct from the older silver sulfadiazine cream that’s no longer first-line. The household version of “what to do with a burn” is simpler than what most of us grew up teaching: water, time, clean cover.

Splints, briefly. One 36-inch SAM splint covers the realistic home use case. Radiolucent, reusable, immobilizes wrist, forearm, ankle, and cervical spine when folded. Add a triangular bandage and a couple of ACE wraps. 

One frame to hold through the rest of this: kits scale with capability. A household with a trained member can credibly carry a higher-tier kit. The category is appropriate medical preparation, sized to capability.


Water and sanitation

Back to fundamentals here. In austere medicine, dehydration is the leading preventable cause of death, and sanitation failures drive much of the rest. The kit answer for both is cheap and simple.

Start with safe water. Ready.gov’s anchor is 1 gallon per person per day¹¹. Treat the source with whatever you have available. Boiling for 1 minute (3 minutes above 6,500 feet) is the gold standard. Unscented household bleach (5 to 9% sodium hypochlorite) works at 8 drops per gallon of clear water or 16 drops per gallon of cloudy water, 30 minute contact time¹². For filtration, the spec that matters is “≤1 micron absolute,” which screens out Giardia and Cryptosporidium; viruses still need chemical disinfection on top.

Then rehydration. The WHO low-osmolarity oral rehydration salt formula (75 mEq sodium, 75 mmol glucose, 20 mEq potassium, 10 mEq citrate per liter) is the standard¹³. Commercial ORS packets are cheap to stock; the home recipe in a pinch is 1 liter of clean water, 6 level teaspoons of sugar, and half a teaspoon of salt. One thing worth telling patients over and over again: adult sports drinks are not pediatric ORS. The sodium is too low and the sugar is too high to treat clinical dehydration in a child, and this really matters when the household has small kids and no power.

Infection prevention is the third leg, and it’s mostly about hand hygiene and a few pieces of PPE. CDC guidance: soap and water for 20 seconds, 60% alcohol hand rub as backup, nitrile gloves (not latex), N95 respirators for smoke and infectious exposure, household bleach for surface disinfection¹⁴. Gloves don’t replace handwashing. We all know to wash our hands. This is the reminder: scrub them, and scrub them well. As basic as it gets, and as load-bearing as anything in the kit.


Power, monitoring, documentation, communication

Four things beyond the supplies themselves. Power: durable medical equipment needs a backup plan. CPAP and BiPAP units run off a portable battery overnight; oxygen concentrators draw too much for that, and the answer is standby tanks, not bigger batteries.

The refrigerator is the harder problem.  I know you’re already thinking about insulin, because the idea of a disaster panics any diabetic patient. Insulin is stable at 59 to 86°F for up to 28 days unopened, per FDA emergency guidance⁴. Do not freeze. Use it warm before going without.


Beyond the insulin window, GLP-1 agonists run 14 to 56 days at room temperature depending on product (Ozempic 56 days at up to 30°C, Trulicity 14)¹⁵. Most injectable biologics fall in a similar window. The point a patient needs to hear in the office, before a hurricane forecast lands: check the package insert for the room-temp tolerance of their specific medication, pack a cooler with ice packs (not direct contact), and don’t freeze any of it.

Monitoring: a thermometer, a validated home blood pressure cuff, a glucometer for diabetics, and a pulse oximeter cover the household use case, with the FDA Safety Communication caveat that pulse-ox devices overestimate true saturation in darker-skinned patients¹⁶. Skip the otoscope; non-clinicians can’t reliably interpret what they see. 

Documentation: the patient’s kit should include a written med list with doses, an allergy list, photos of every pill bottle (the label itself is a functional clinical document), insurance and immunization records, an advance directive, and recent labs on a thumb drive. HIPAA doesn’t block emergency disclosure¹⁷. 

Communication: four pre-emergency setups worth pushing at a routine visit. Patient portal credentials stored somewhere accessible, the prescriber’s direct line saved, a regional telehealth fallback identified before the season, and a backup ER chosen if the usual system is overwhelmed.


Pediatric, mental health, household specifics

A generic kit doesn’t fit a specific household. Here’s a few specific populations who need specialized resources in an emergency. 

Pediatric. Weight-based dosing for acetaminophen, ibuprofen, diphenhydramine, and ondansetron printed on a card the household can read at 2am¹⁸. Pediatric ORS, not adult sports drinks. Ready-to-feed formula in any household with an infant; powder requires safe water that may not be available. Children’s medication doses can be improvised from adult bottles sometimes if truly needed, but beware your numbers: the math is the most common error in field pediatric care.

Mental health. Continuity of psychiatric medications is the under-discussed half of disaster planning. SSRIs, mood stabilizers, antipsychotics, and benzodiazepines: discontinuation syndromes and decompensation are the predictable failure modes when an evacuation runs longer than the on-hand supply. The Schedule II hardship from Module 1 lives here too; stimulants and opioids are the gap. Brief acute insomnia in a sheltered population is expected and self-resolves; eye masks and earplugs are kit items worth recommending.

Pregnancy. A pregnant patient needs an earlier evacuation trigger, a clean emergency birth kit, and prenatal vitamins added to the chronic supply per ACOG¹⁹.

Older adults on polypharmacy need indications named on the med list, not just drug names, plus spare hearing-aid batteries and glasses.

A dental emergency kit (Dentek temporary filling, clove oil, ibuprofen-acetaminophen combo) covers most field dental needs; antibiotics for systemic signs only, ER for swelling extending under the tongue or to the eye.


Capability, and the cliff

A kit you don’t know how to use is decoration. The previous five modules describe the contents of a household’s medical preparation; this one describes what makes that preparation actually work.

Capability is training. Stop the Bleed certification, a basic wound care class, comfort with the medications in the kit, a household conversation about who in the family knows what. Most of this is free or close to it. None of it gets done if we as the clinician haven’t said it out loud during a routine visit.

Which brings us to the cliff.

Patients are figuring this out themselves. They are Googling at 1am and going down Reddit rabbit holes. They are taking dosing advice from prepper forums because the clinical voices have stayed quiet. Healthcare’s collective response to “what should I reasonably have on hand?” has been to hedge or say, ‘you can’t have any prescription on hand ahead of time. That’s not responsible. You’ll be treated only after you need it”. 

The void doesn’t stay empty; somebody fills it.

The failure is at the category level. We never named the thing the patient was asking about, so we never built the framework for thinking about it. The category has a name now: appropriate medical preparation. The framework is the five modules above. The work is making sure the patients in our practices encounter our voice in this space before they encounter someone else’s.

A few of us are charting the grey area in public. We are publishing the criteria, the dosing thresholds, the kit composition, the indications, and the limits, week after week, so that what a curious patient finds when they search is a clinician’s framework rather than a forum’s. This is the work Jase exists to do. If you have patients asking the SHTF question and you want a clinically rigorous resource to point them to, we work with HCPs directly. The goal is not to sell to your patient. It’s to make sure your patient has the guidance of clinical help in this emerging area.


Sources

  1. Greenough PG, Lappi MD, Hsu EB, et al. Chronic Disease and Disasters: Medication Demands of Hurricane Katrina Evacuees. American Journal of Preventive Medicine. 2007;33(3):207-210. PubMed: 17826580.
  2. Ready.gov, Build A Kit (3-day baseline). ready.gov/kit
  3. Healthcare Ready, A Review of State Emergency Prescription Protocols; supporting disaster medicine literature on 30 to 90 day chronic-medication supply.
  4. FDA, Information Regarding Insulin Storage and Switching Between Products in an Emergency.
  5. DEA Pharmacist’s Manual; Healthcare Ready, Review of State Emergency Prescription Protocols (Schedule III through V emergency dispensing coverage varies by state).
  6. American College of Surgeons / Stop the Bleed, kit composition and CoTCCC-listed contents.
  7. Goolsby C, et al., skill-retention data on Stop the Bleed training (the underlying evidence base for the 1 to 2 year refresh recommendation).
  8. Wilderness Medical Society, Basic Wound Management in the Austere Environment (2014 practice guidelines).
  9. American Academy of Family Physicians, wound care evidence: petrolatum vs. triple-antibiotic ointment.
  10. American Burn Association field guidance; Annals of Emergency Medicine (2025), Cool Running Water as a First Aid Treatment for Burn Injuries. PubMed: 40985917.
  11. Ready.gov, Build A Kit (water anchor: 1 gallon per person per day). ready.gov/water
  12. CDC, Making Water Safe in an Emergency; CDC water filtration guidance (the ≤1 micron absolute filter spec for Giardia and Cryptosporidium).
  13. World Health Organization, Oral Rehydration Salts: Production of the new ORS.
  14. CDC, Guidelines for Personal Hygiene During an Emergency; supporting CDC respiratory protection and wildfire smoke guidance for N95 use.
  15. GLP-1 manufacturer prescribing information (Novo Nordisk for Ozempic, Eli Lilly for Trulicity, current US labeling).
  16. FDA Safety Communication: Pulse Oximeter Accuracy and Limitations (2021, updated 2022).
  17. ASPR-TRACIE, HIPAA and Disclosures in Emergency Situations fact sheet.
  18. AAP pediatric dosing charts (acetaminophen and ibuprofen); Lexicomp Pediatric and Harriet Lane (diphenhydramine and ondansetron weight-based dosing).
  19. American College of Obstetricians and Gynecologists Committee Statement No. 15 (January 2025): Preparing for Disasters: Addressing Critical Obstetric and Gynecologic Needs of Patients.

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For Clinicians | Azithromycin (Z-Pack): Why It Earns a Place in Appropriate Medical Preparation

For Clinicians | Azithromycin (Z-Pack)

Why It Earns a Place in Appropriate Medical Preparation

By Dr. Jamie Wilkey, PharmD — Director of Clinical Strategy, Jase
Edited and approved by Kristen Carpenter, PA-C — Clinical Advisory Board Member

Can’t you just call in a Z-Pack?

Your patients probably ask for one all the time. They know it works, and almost everyone has taken one at some point in their life.

Today we’re talking about the Z-Pack and why it’s so helpful for appropriate medical preparation across a number of different common conditions. What it’s approved to treat. What it’s actually being used for. And where the line sits between what’s okay for a patient to keep on hand and what still needs to be seen by a doctor.


What is azithromycin, and what does it treat?

Azithromycin is a macrolide antibiotic, FDA-approved for a number of common bacterial infections.¹ Most courses run 3 to 5 days, with one-time single-dose regimens for a few specific indications.

A few things make it useful when access to care is delayed:

  • The course is short. The drug accumulates in tissue and has a prolonged terminal half-life, which clinically supports a short course providing antimicrobial activity beyond the dosing window.²
  • It covers the common community-acquired pathogens behind respiratory infections, skin and soft tissue infections, certain sexually transmitted infections, and traveler’s diarrhea.¹
  • It’s a real option for patients who can’t take penicillin, which is a larger group than most clinicians realize.
  • It’s oral, well-tolerated, and inexpensive.

FDA-approved indications include:¹

  • Acute bacterial sinusitis
  • Acute bacterial exacerbation of chronic bronchitis (mild to moderate)
  • Community-acquired pneumonia (mild severity, suitable for outpatient oral therapy)
  • Pharyngitis and tonsillitis as an alternative to first-line therapy in penicillin-allergic patients
  • Uncomplicated skin and skin structure infections
  • Urethritis and cervicitis due to Chlamydia trachomatis or certain gonococcal infections
  • Genital ulcer disease due to chancroid
  • Acute otitis media in pediatric patients

Guideline-supported uses outside the FDA label:

  • Traveler’s diarrhea, particularly in regions where fluoroquinolone-resistant Campylobacter is common (notably Southeast Asia).³
  • Pertussis treatment and post-exposure prophylaxis.⁴
  • MAC prophylaxis in HIV patients with CD4 <50 not on effective ART, and as part of combination treatment for disseminated MAC.⁵

Why azithromycin is in the JaseCase

We here at Jase provide, ahead of time, the medications patients need for a number of emergencies, and azithromycin is one of our favorites.

When a patient picks up a prescription at their regular pharmacy, the clinical work has already been done: the diagnosis is confirmed, the indication is documented, the dosing is verified, and the pharmacist is two steps from the prescriber if anything looks off. Contingency stocking removes all of those backstops. The protocol, the indication match, the dosing, the dispensing instructions, and the patient education all have to be locked before the bottle goes on the shelf.

Jase is in a unique position to help patients proactively. We prescribe for a select set of emergencies, before they happen, at the same clinical standard a patient would receive in the room. Azithromycin earns its place in the JaseCase against a specific set of criteria for contingency use:

Indication breadth. One molecule covers the common community-acquired infections a patient is most likely to encounter outside business hours: a sinus infection that goes brutal on day three, a respiratory infection that won’t quit, a strep-positive kid who can’t take amoxicillin, a chlamydia exposure that needs treating, traveler’s diarrhea that hits halfway through a trip. Stocking one drug that addresses several presentations is more useful in a kit than stocking five drugs each addressing one.

Fixed, short dosing. A 3 to 5 day course with no titration, no renal dose adjustment in the typical adult, no requirement for serum levels, and no repeat dosing decisions. The course we wrote ends when the package ends.

Penicillin alternative. About 10% of the U.S. population carries a documented penicillin allergy on their chart.⁶ The true IgE-mediated rate is closer to 1%, but the labeled-allergy patients still avoid penicillin-class drugs in real practice because confirming the true rate requires testing most patients haven’t had. Amoxicillin-clavulanate is the other common kit antibiotic, and for roughly one in ten patients it isn’t an option. Azithromycin is.

Familiarity that reduces error. Roughly 10.3 million prescriptions for azithromycin are written every year in the U.S., making it the 64th most-commonly prescribed medication in the country.⁷ The patient has likely taken it. The prescriber writes it from muscle memory. The protocol Jase delivers with the kit slots into a pattern both already know. Familiar drugs are safer drugs in contingency use.

Storage and stability. Tablets, room temperature, multi-year shelf life. The drug stays viable in a kit on a shelf at home or in a glovebox on the road.

This is how we treat all the drugs in our JaseCase. They’re very carefully selected.


Azithromycin at a glance

The view for the indications most likely to come up when a patient reaches for their kit. Doses are adult standard unless noted.

Don’t reach for azithromycin for:

  • Viral upper respiratory infections. Antibiotics don’t help. Symptomatic care.
  • Suspected gonorrhea. CDC now recommends ceftriaxone monotherapy; azithromycin is no longer routinely added.⁸
  • Suspected MRSA skin or soft tissue infections.
  • Anything escalating: high fever, sepsis signs, immunocompromise, hemodynamic instability, or systemic involvement.
  • Bacterial infections where a beta-lactam is first-line and the patient is not actually penicillin-allergic. Use the right tool.

Two cautions worth flagging:

  • QT prolongation. Use caution in patients with known QT prolongation, electrolyte derangements, or concurrent QT-prolonging medications.⁹
  • Macrolide resistance. Pneumococcal macrolide resistance is significant and varies by region. For pneumonia in particular, current resistance patterns matter for empiric choice.

Stewardship is the bar, not the brake

The answer is the clinical work that happens before the bottle ever ships, while the situation is still calm and considered. For contingency stocking, the prescriber isn’t going to see the patient at the moment of use, so the screening has to be stricter on the front end, not looser. We review the patients current medical conditions, medications, and any allergies they may have to determine if the case medications would be safe for them to take. Patients complete an intake and attestations, a licensed prescriber reviews them against those criteria, and the kit ships only when the fit is appropriate. The patient isn’t reaching into the cabinet on instinct. They are reaching for a medication a prescriber already cleared for them, before they ever got sick.


Each medication in the kit ships with an information sheet: basic drug information, common side effects, contraindications, and dosing for common conditions. The sheets aren’t a diagnostic tool. They are reference materials patients can use to follow the prescriber’s plan and bring accurate information into the room if they end up in front of another clinician. Our team can answer clarification questions about how the medications work. We are not the patient’s treating clinician, and the kit is not a substitute for primary care.

Contingency stocking in this category needs to clear a higher stewardship bar than routine office prescribing, not a lower one. The patient is going to be at home, at a campsite, on a cruise ship, in a hotel halfway across the world, somewhere the prescriber can’t see them. That changes the protocol design. It does not relax it.


Who makes these calls

Our team is medical doctors, physician assistants with field experience in disaster medicine and humanitarian response, and pharmacists. The clinical work happens on the front end, so the patient isn’t doing it alone at 11pm.

Kristen Carpenter, PA-C, put it this way when we mapped out the JaseCase formulary:

When we decided which antibiotics belonged in the JaseCase, azithromycin was an easy choice. It’s a broad-spectrum antibiotic that can treat a number of different bacterial infections. It is fast acting, usually requires shorter treatment courses, compared to other antibiotics, and is a great alternative for people who are allergic to, or cannot get, penicillin, offering a necessary backup in a limited-supply scenario.


Charting the grey area in public

Contingency stocking for predictable, common emergencies is a real clinical category, and the guidelines haven’t caught up to it yet. Our team is publishing how we make these calls, the criteria we use to add or exclude a drug, and the protocols we deliver with each kit.

If a patient keeps asking and you’d rather not take on the contingency work yourself, you can refer them to us at Jase.com. It’s a clinical handoff, not a product pitch.

Public knowledge gets better when clinicians chart the grey area in public instead of letting the internet do it. The category is going to fill in. The question is who fills it in, and with what standard.


The bottom line

Azithromycin earned its place in the JaseCase on clinical merit: indication breadth, short fixed-course dosing, a real penicillin alternative, familiarity, and shelf stability. The same screen applies to every drug we add. This is not a replacement for primary care. It is the bridge for the moments primary care isn’t there. Trusted medicine, on your patient’s shelf, before the moment they need it.

To learn more, check us out at Jase.com.


Sources

  1. FDA Zithromax (azithromycin) prescribing information. Indications and Usage; Dosage and Administration. DailyMed: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=db52b91e-79f7-4cc1-9564-f2eee8e31c45
  2. FDA Zithromax (azithromycin) prescribing information, Clinical Pharmacology section (pharmacokinetics: tissue distribution and prolonged terminal half-life). Same DailyMed reference as #1.
  3. CDC Yellow Book, Travelers’ Diarrhea chapter. Azithromycin first-line empiric treatment in Southeast Asia and other regions with fluoroquinolone-resistant Campylobacter. https://www.cdc.gov/yellow-book/hcp/preparing-international-travelers/travelers-diarrhea.html
  4. CDC. Pertussis (Whooping Cough): Treatment and Post-Exposure Prophylaxis. https://www.cdc.gov/pertussis/hcp/clinical-care/index.html (treatment overview); https://www.cdc.gov/mmwr/pdf/rr/rr5414.pdf (MMWR RR-54/14, 2005, for dosing).
  5. NIH/CDC/IDSA. Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV: Mycobacterium avium Complex. Azithromycin is the preferred agent for primary prophylaxis (CD4 <50 not on effective ART) and a preferred first agent as part of combination treatment for disseminated MAC. https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/disseminated
  6. CDC. Evaluation and Diagnosis of Penicillin Allergy for Healthcare Professionals. ~10% of U.S. patients report a penicillin allergy; <1% are truly allergic. https://www.cdc.gov/antibiotic-use/hcp/clinical-signs/index.html. Supporting: Castells M, Khan DA, Phillips EJ. “Penicillin Allergy.” N Engl J Med 2019;381:2338-2351.
  7. ClinCalc DrugStats Database. Azithromycin: estimated 10,337,595 U.S. prescriptions (2023), ranked #64 among the most-commonly prescribed medications. https://clincalc.com/DrugStats/Drugs/Azithromycin
  8. CDC Sexually Transmitted Infections Treatment Guidelines, 2021. Gonococcal infections: ceftriaxone monotherapy (500 mg IM single dose for patients <150 kg). Azithromycin is no longer routinely added to dual therapy. Chlamydial infections: doxycycline 100 mg BID x 7 days is the recommended regimen; azithromycin 1 g single dose is listed as an alternative. https://www.cdc.gov/std/treatment-guidelines/gonorrhea-adults.htm and https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm
  9. Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM. “Azithromycin and the Risk of Cardiovascular Death.” N Engl J Med 2012;366:1881-1890. FDA Drug Safety Communication, March 2013: azithromycin QT prolongation risk. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-azithromycin-zithromax-or-zmax-and-risk-potentially-fatal-heart. Current Zithromax label includes QT prolongation in Warnings.

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For Clinicians | Natural Disaster Preparedness: The Medical Framework Most Emergency Kits Miss

For Clinicians | Natural Disaster Preparedness

The Medical Framework Most Emergency Kits Miss

By Dr. Jamie Wilkey, PharmD — Director of Clinical Strategy, Jase
Edited and approved by Kristen Carpenter, PA-C — Clinical Advisory Board Member


Are families actually prepared for natural disasters?

Most aren’t. Not because they don’t care. Not for lack of being told to prepare. We prescribers haven’t done the proactive work. Families don’t know what they actually need on hand, or what to prepare for medically.

A 72-hour kit and a flashlight aren’t a medical plan. A bandage and a bottle of Tylenol aren’t a medical plan. Prescriptions and medical supplies are the part most checklists skip. We prescribers have to make sure that part is right.

This article is that framework. It pulls together the patient-facing components Jase has been building for years: the 72-hour kit, the family communication plan, and wound care. The clinical layer sits on top of all three.


Most of us had a lecture on disaster medicine. Few of us had to use it.

Pharmacy school, medical school, PA school all covered it. A slide deck, maybe a chapter on triage in a mass-casualty event. Then we moved on. Most of us didn’t think about it again until it was actively happening to a patient, or to us.

That’s the muscle we’re training now, and it has to cover more than the big ones. Two categories matter here.

Natural disasters are usually few and far between for individual families, but of epic proportions when they happen. Evacuation across state lines at 2am because of a wildfire. Pharmacies underwater for a week after a flood. An earthquake that closes the only urgent care in the county. The ER two counties away after a hurricane knocks out the closer ones. These are the ones that make the news. The families who do well didn’t assume the system would be there afterward. They got medically ready before the storm had a name.

Situational disasters are the everyday version. The disaster isn’t the weather. It’s the access gap itself. The patient who lives 90 minutes from urgent care and gets a UTI on a Friday night. The family on a cruise when a kid spikes a fever and the nearest English-speaking pharmacy is closed. The traveler whose refill won’t arrive before the flight. The toddler whose ear infection announces itself at 11pm on a Saturday in a town with no 24-hour pharmacy. These don’t make the news. They happen every week, to most of our patients. They hit the same access gap as the natural disasters. Just smaller.

The framework has to serve both. Our patients don’t have time to wait while we figure it out in the moment. The job is to think proactively. Build the framework once. Have a ready answer for what they need, before they need it.

Patients are already figuring it out on their own. Prepper internet, TikTok dosing advice, online forums, the friend-of-a-friend who knows a guy. When clinicians don’t chart this space, the internet does. The answers patients find range from reasonable to reckless.


What medication readiness actually looks like

Two layers, both clinical. The first keeps the patient’s current regimen intact. The second covers what the disaster predictably brings.

Layer 1: Chronic continuity
Every patient with a chronic medication needs at least a 90-day supply on hand. Insurance vacation overrides and mail-order fills are the standard mechanisms; coverage varies by state and insurer.

The written medication list is the second half. It is the part that gets skipped most often. Keep one page on the patient or in their go-bag. List every medication by name, dose, prescribing physician, and the pharmacy that actually fills it. With that list in hand, a pharmacist who’s never seen them before can help them so much more easily. Without it, the patient is trying to remember their own regimen under stress.

Layer 2: Acute contingency
This layer covers what the disaster predictably causes.

When water and sanitation fail, GI infections spike. When evacuation shelters fill up, skin and wound infections follow.1 UTIs don’t pause for the storm. Respiratory exacerbations get worse in smoke or mold. Pediatric ear infections happen on the same Saturday night they always do. This time, in a town where the 24-hour pharmacy just closed. These are predictable conditions with well-defined treatment paths. They don’t need a new clinical decision in the moment. They need access in the moment.

That means a prescription contingency layer. Antibiotics for the UTI, skin, respiratory, and GI infections disasters predictably cause. Anti-emetic, anti-diarrheal, and oral rehydration for when IV access isn’t on the table. The JaseCase covers this. A clinician prescribes ahead, evaluates the patient’s history, and counsels on appropriate use.

Think of it this way. Telehealth already prescribes for most of these conditions reactively. Layer 2 is the same prescribing, moved earlier in the timeline. The decision tree is short. The evidence base is solid. The medication ends up with the same patient either way. The only thing that changes is whether they have it when they need it.


What disasters predictably cause, and what to have ready

Different disasters drive different clinical needs. The pattern is consistent enough to build a reference you can carry into the room:

Disaster type Predictable medical needs
Wildfire / smoke event Respiratory exacerbations, eye irrigation, refill disruption
Flood / hurricane GI infections from contaminated water, skin and wound infections, mosquito-borne, mold-triggered respiratory
Earthquake / tornado Traumatic injuries, debris wounds, crush, contamination, local mass-casualty triage
Extended power loss Insulin and refrigerated medications, CPAP and oxygen disruption, heat illness
Extreme heat Heat exhaustion and heatstroke, dehydration, cardiac and respiratory exacerbation, medication temperature instability
Winter storm / extreme cold Hypothermia, frostbite, CO poisoning from indoor heating workarounds, refill and supply disruption

The prescription contingency layer maps cleanly onto this:

  • Skin and wound infections: amoxicillin-clavulanate, doxycycline, clindamycin
  • GI infections from contaminated water: ciprofloxacin, TMP-SMX, metronidazole
  • UTIs (which happen disaster or not): ciprofloxacin, TMP-SMX
  • Broad-spectrum for high-contamination wounds: amoxicillin-clavulanate, doxycycline

The point of the table is not to memorize coverage. It’s a quick reference for what to keep an eye out for, given the disaster type most likely in your area. A clinician in coastal Florida prepares a different list than one in tornado country or wildfire county.

 


Beyond the prescription layer: the survival-medical basics most kits get wrong

Three pieces patients consistently under-pack:

  • Water. A filter that handles both viruses and bacteria, not just bacteria. Most consumer filters miss viruses.2 Add a chlorine or boiling protocol the family has actually practiced.
  • Wound care. Most wounds heal without antibiotics. Clean with tap water and soap. Keep moist with petroleum jelly, not OTC antibiotic ointment.3 Then monitor. Prophylactic antibiotics matter for contaminated wounds, non-potable water exposure, bites, sensitive locations, and patients who are diabetic or immunocompromised.4.
  • OTC. Pain, fever, allergy, anti-emetic, anti-diarrheal, and oral rehydration. The standard kit skews toward pain and antacids. Anti-emetic and oral rehydration are the missing pieces.

The category has a name: appropriate medical preparation. It covers self-limiting, predictable, well-understood conditions. Prescribing ahead is clinically identical to prescribing at the moment.


Charting this grey area in public

Jase’s team includes board-certified family medicine physicians. Our physician assistants have field experience in disaster medicine and humanitarian response. The clinical work happens on the front end. The patient isn’t doing it alone at 11pm in a town where urgent care just closed.

Public knowledge gets better when we chart the grey area in public. Otherwise, the internet does it for us. If you don’t have bandwidth to build a medical readiness plan in the room, you can refer patients to us at Jase.com. We’ll keep sharing frameworks and decision criteria here as we go.

We link three patient-facing guides below. They cover the 72-hour kit, the family communication plan, and wound care. The JaseCase covers the prescription contingency layer for families who want to go further. FirstAid sits alongside it for wounds and injuries. Bunker in a Box handles the longer haul. None of this replaces primary care. It exists for the times primary care isn’t reachable.


Sources

  1. Centers for Disease Control and Prevention. “Vibrio Illnesses After Hurricane Katrina, Multiple States, August–September 2005.” MMWR Morb Mortal Wkly Rep. 2005;54(37):928-931. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5437a5.htm
  2. Centers for Disease Control and Prevention. “About Water Treatment Options When Hiking, Camping, or Traveling.” Drinking Water Prevention guidance, 2025. https://www.cdc.gov/drinking-water/prevention/water-treatment-hiking-camping-traveling.html
  3. Smack DP, Harrington AC, Dunn C, et al. “Infection and Allergy Incidence in Ambulatory Surgery Patients Using White Petrolatum vs Bacitracin Ointment: A Randomized Controlled Trial.” JAMA. 1996;276(12):972-977. https://jamanetwork.com/journals/jama/article-abstract/408314
  4. Stevens DL, Bisno AL, Chambers HF, et al. “Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America.” Clin Infect Dis. 2014;59(2):e10-e52. https://academic.oup.com/cid/article/59/2/e10/2895845
  5. Centers for Disease Control and Prevention. “What to Do After a Hurricane or Flood: Mosquitoes.” https://www.cdc.gov/mosquitoes/response/index.html
  6. Centers for Disease Control and Prevention. “Use of Carbon Monoxide Alarms to Prevent Poisonings During a Power Outage, North Carolina, December 2002.” MMWR Morb Mortal Wkly Rep. 2004;53(09):189-192. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5309a1.htm

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Measles, Dengue, and the World Cup: The 20-Minute International Travel Checklist We Use Before Every Trip

Measles, Dengue, and the World Cup: The 20-Minute International Travel Checklist We Use Before Every Trip

By Cayla McGrath
Edited and approved by Kristen Carpenter, PA-C — Clinical Advisory Board Member

For many soccer fans, attending the FIFA World Cup is a once-in-a-lifetime experience. The 2026 tournament is expected to be the largest in history, with matches spread across the United States, Mexico, and Canada and millions of fans traveling from around the world to be part of it. Flights are booked. Hotels are filling up. Families and friend groups are already planning the international travel trips they’ve dreamed about for years.

At the same time, travel headlines this summer have been filled with news about measles outbreaks, dengue activity, cruise ship illnesses, and evolving CDC travel notices. It can be difficult to know what actually matters, what doesn’t, and whether any of it should change your plans.

Here’s the good news: none of these headlines are a reason to cancel your trip.

They are, however, a reminder that international travel is easier when you spend a few minutes preparing before you leave.

One of the biggest misconceptions about travel health is that it’s mostly about rare diseases in faraway places. In reality, the issues most likely to affect travelers are often much more ordinary: a vaccine you forgot to check, a medication that runs out halfway through a trip, a case of travelers’ diarrhea, a mosquito-borne illness that’s active in the region you’re visiting, or a common infection that becomes surprisingly difficult to treat when you’re navigating an unfamiliar healthcare system.

The good news is that addressing most of those risks doesn’t require hours of research or a complicated medical plan. In fact, the same checklist our team of physicians, physician assistants, and pharmacists uses before international travel can be completed in about 20 minutes.

Here’s what we recommend checking before you go.


Start With the CDC International Travel Notices

Before any international travel, one of the smartest things you can do is spend a few minutes reviewing the CDC’s travel notices for your destination. These notices change regularly and provide updates on outbreaks, disease activity, and health recommendations specific to where you’re traveling. This year, measles and dengue are two of the most notable concerns appearing across multiple destinations.

The CDC has issued a global dengue advisory covering more than 100 countries, and dengue activity remains elevated across many popular travel destinations throughout Latin America, the Caribbean, and tropical regions around the world. For most travelers, the takeaway isn’t panic. It’s awareness. Knowing what’s active at your destination helps you make informed decisions before you board the plane.


Verify Your Vaccines Before You Leave

If there’s one item on this year’s checklist that deserves special attention, it’s measles protection. Many adults assume they’re protected because they were vaccinated as children, and most are. However, healthcare professionals are encouraging travelers to verify their vaccination status, especially if records are incomplete or uncertain.

This is particularly relevant for travelers heading to World Cup host cities, where large crowds and international travel create ideal conditions for infectious diseases to spread.

For many people, confirming vaccination status takes just a few minutes through a healthcare provider, patient portal, or immunization record system.

It’s one of the easiest items on the list—and one of the highest impact.


Understand the Difference Between Health Risks and Travel Disruptions

One thing the CDC board doesn’t always capture is the difference between a serious health threat and a trip disruption.

For example, a recent hantavirus outbreak on an Antarctic cruise ship generated significant headlines. While the story was alarming, public health authorities assessed the broader risk as low. Meanwhile, far more travelers will lose vacation days this year to things like travelers’ diarrhea, respiratory viruses, motion sickness, dehydration, or a urinary tract infection than they ever will to a rare infectious disease.

This distinction matters because most travel health preparation should focus on what is likely, not simply what is newsworthy.

A day spent recovering in your hotel room because you couldn’t find treatment for a common illness can derail a trip just as effectively as something much rarer.


Pack for the Problems Most International Travelers Actually Face

When our clinical team prepares for travel, we don’t build a suitcase around worst-case scenarios.We build it around common ones.

A small travel health kit should be able to handle minor injuries, dehydration, motion sickness, blisters, and other everyday issues that frequently arise during travel. Bandages, wound care supplies, electrolyte packets, a thermometer, and basic over-the-counter medications cover a surprising number of situations.

Beyond that, we think about access. What happens if someone develops a UTI on day four of a two-week trip? What if travelers’ diarrhea strikes halfway through a vacation? What if a common infection appears while you’re in a foreign country where prescriptions don’t transfer and healthcare systems operate differently than they do at home?

Those are not rare scenarios. They’re predictable ones.

That’s why our team approaches travel preparedness through the lens of Appropriate Medical Preparation. The goal isn’t to prepare for everything. It’s to prepare for the things most likely to interrupt your trip and create unnecessary stress.


Don’t Assume a Foreign Pharmacy Will Solve the Problem

One of the biggest mistakes travelers make is assuming they’ll simply buy what they need if something comes up. Sometimes that works. Often it doesn’t.

Prescription laws vary dramatically from country to country. Medications may be sold under different names. A prescription from your physician at home may not be valid abroad. Some medications available in the United States face restrictions elsewhere, while medications sold over the counter in another country may differ significantly from what you’re accustomed to using.

By the time many travelers discover these differences, they’re already sick. That’s why our philosophy is simple: if it’s something you know you may need, don’t leave access to chance.


The 20-Minute Pre-Travel Checklist

Before your next international travel, spend 20 minutes working through these four questions:

  1. Have I reviewed the CDC travel notices for my destination?
  2. Is my vaccination status up to date, particularly for measles?
  3. Do I have enough of my routine medications for the entire trip, plus extra time in case of delays?
  4. Do I have a travel health kit that can handle common illnesses and minor medical issues without requiring me to navigate a foreign healthcare system?

If you can answer “yes” to those four questions, you’re ahead of most travelers.


How the Jase Team Travels

At Jase, we spend a lot of time thinking about preparedness because we’ve spent our careers seeing what happens when people don’t have access to what they need.

That doesn’t mean we travel anxiously. Quite the opposite.

The goal of preparation is freedom. When you’ve verified your vaccines, checked destination-specific health notices, packed your medications, and prepared for the most common travel disruptions, you stop worrying about them.

That’s why we don’t view travel preparedness as something separate from travel planning. It’s simply part of traveling well.

The clinicians on our team don’t prepare because they expect something to go wrong. They prepare because they’d rather spend their trip enjoying the destination than trying to find a pharmacy, clinic, or prescription in a city they’ve never visited before.

And that’s exactly what we want for you, too.

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Can You Get Prescription Medication While Traveling Internationally?

Can You Get Prescription Medication While Traveling Internationally?

By Cayla McGrath
Edited and approved by Kristen Carpenter, PA-C — Clinical Advisory Board Member

You’re four days into a trip to Florence when the familiar symptoms start.

You’ve had a urinary tract infection before, so you know exactly what’s happening. Under normal circumstances, it wouldn’t be a major problem. You’d call your doctor, visit urgent care, or pick up the prescription you’ve used before. Instead, you’re sitting in a hotel room halfway around the world trying to figure out how healthcare works in a country where you don’t speak the language, don’t know the system, and aren’t even sure whether the pharmacy down the street can help.

It’s not the sort of problem most travelers spend much time thinking about before they leave home.

Most of us assume that if we get sick while traveling internationally, we’ll simply figure it out when we get there. After all, pharmacies exist everywhere. Doctors exist everywhere. Surely there must be a way to get what you need if something comes up.

Sometimes there is.

Often it’s much more complicated than people expect.


Prescriptions Don’t Travel Easily

One of the biggest surprises for American travelers is that prescriptions don’t travel as easily as they do. A prescription written by your doctor in the United States generally cannot be filled by a pharmacist in Italy, Japan, France, Canada, or most other countries. Prescribing authority is local. If you need a prescription medication abroad, you’ll often need to see a locally licensed physician and obtain a new prescription that complies with that country’s regulations.

Even when medications are available, the experience can be frustrating. Drug names differ from country to country. Medications you’re familiar with may be sold under completely different names, formulations, or packaging. Some medications that are routine in the United States are restricted elsewhere. Certain ADHD medications, decongestants, and controlled substances face significant restrictions in countries such as Japan, while other destinations require documentation that must be arranged before departure.

For travelers managing chronic conditions, the challenge can be even greater. Running low on a blood pressure medication, thyroid medication, or antidepressant halfway through an extended trip isn’t simply inconvenient. It can require navigating a healthcare system you never planned on using, often while trying to enjoy a vacation, attend a business trip, or visit family abroad.


Medication Access

What catches many people off guard is that the difficulty isn’t usually the illness itself. It’s access.

A recurring UTI is still a recurring UTI whether you’re in Ohio or Florence. Travelers’ diarrhea is still travelers’ diarrhea whether you’re in Cancún or Chicago. The medical issue may be straightforward. The challenge is obtaining timely care in an unfamiliar place after the problem has already started.

This is why so many experienced travelers think differently about preparation. The best travel preparation isn’t about expecting disaster. It’s about recognizing that certain situations are predictable. Travelers get gastrointestinal illnesses. People with a history of recurrent UTIs sometimes get another one. Prescriptions occasionally run low. Flights get delayed. Trips get extended. The question isn’t whether every traveler will encounter one of these problems. The question is whether you’ll have a plan if you do.


Plan Ahead

At Jase, we believe that plan should begin before departure.

Our team of physicians, physician assistants, and pharmacists created Jase because we repeatedly saw patients trying to solve predictable healthcare problems at the least convenient possible moment. The traveler with a UTI on day four of a two-week vacation. The retiree who realizes they packed thirty days of medication for a thirty-five-day trip. The family trying to find an English-speaking doctor in a foreign city for something that could have been anticipated weeks earlier.

Those experiences don’t usually become medical emergencies. They become unnecessary disruptions.

That’s why we approach travel preparedness differently. Rather than asking people to navigate unfamiliar healthcare systems after they become sick, we focus on helping them prepare before they leave. A licensed U.S. clinician evaluates whether preparedness medications are appropriate for a person’s medical history and travel plans. If they are, those medications are dispensed through a licensed U.S. pharmacy and accompanied by clear guidance for when and how they should be used.

This isn’t a replacement for primary care. In fact, it’s built on the same philosophy that drives good primary care: thoughtful planning, risk reduction, and helping patients stay ahead of problems rather than reacting to them. Your physician remains your physician. Jase simply helps fill the gap that exists when you’re thousands of miles away and that relationship isn’t immediately accessible.

Many travelers spend hours researching hotels, restaurants, transportation, and attractions before a trip. Few spend even a few minutes thinking about how they would access medical care if they needed it. Yet anyone who has ever spent a day of their vacation sitting in a waiting room or searching for a pharmacy in a foreign city understands how valuable that preparation can be.

We call this Appropriate Medical Preparation.

It’s not about expecting the worst. It’s not about packing a suitcase full of medications “just in case.” It’s about recognizing that access to healthcare becomes more complicated when you leave home and taking reasonable steps to prepare for that reality.

Because the goal of your trip should be enjoying Florence, Tokyo, Cancún, or wherever your travels take you—not spending half a day trying to figure out how to get a prescription filled once you’re already sick.

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