One of the Greatest Discoveries Since the Wheel


Over the years many lists have been published in an effort to rank the most “revolutionary inventions or discoveries in history”, or the “greatest breakthroughs of all time”. Invariably these lists include “penicillin” or “antibiotics”. In fact, a list published by The Atlantic in 2013 listed the discovery of penicillin in 1928 as number three in their article of “The 50 Greatest Breakthroughs Since the Wheel”.

The discovery of penicillin by Alexander Fleming in St. Mary’s Hospital, London ushered in the modern age of medicine. He is credited with the following quote, “One sometimes finds what one is not looking for. When I woke up just after dawn on Sept. 28, 1928, I certainly didn’t plan to revolutionize all medicine by discovering the world’s first antibiotic, or bacteria killer. But I guess that was exactly what I did.”

So why, exactly, was Fleming’s discovery so revolutionary? Prior to the beginning of the 20th century, bacterial infections accounted for the top causes of death in the world. The average life expectancy was just 47 years. Diseases like cholera, pneumonia, tuberculosis were rampant. The antibiotic era revolutionized the treatment of infectious diseases. The average life expectancy rose to 79 years. Antibiotics and other factors like improved sanitation, vaccinations, public health measures, and education are the reasons developed nations such as the United States have seen such a dramatic increase in overall life expectancy and quality of life.

With such impactful consequences to humankind it is easy to see how the discovery of penicillin warrants a top 3 placement in “The 50 Greatest Breakthroughs Since the Wheel”. We have grown so accustomed to the use of antibiotics that it is hard to imagine a world where once again infectious disease becomes a top killer. By preparing for the worst and hoping for the best, we at JASE Medical are on a mission to provide everyone the opportunity to ensure themselves and their families piece of mind should, one day, a world where antibiotics are in short supply or impossible to obtain becomes a reality.


When Do My Antibiotics Expire?


When you receive your antibiotics you will see a ‘use by’ date printed on the prescription label. Most states require pharmacists to print a ‘use by’ date one year from the date the prescription was filled. Don’t confuse this ‘use by’ date with a true expiration date. This one-year date is how long until the PRESCRIPTION expires. The actual expiration of the medication is another matter. In the case of antibiotics, the subject has undergone extensive study.

Since 1979 in the United States all drug manufacturers are required to place an expiration date on their products. The expiration date printed by the manufacturer represents the date by which full potency and safety of the drug can be guaranteed. However, most drug companies don’t have the motivation to study their product for years and years to demonstrate how effective or safe the medication may be after 5, 10, 20, or more years.

Fortunately, there is an on-going and extensive study undertaken by the FDA on behalf of the United States Department of Defense. The so-called ‘Shelf Life Extension Program’ (SLEP) was commissioned to reduce medication costs for the military. The military maintains large stockpiles of supplies including medications and was having to rotate their stock regularly due to published expiration dates from the drug manufacturers. This constant need for stock rotation was expensive and efforts were made to study the potency and safety of medication beyond its printed expiration. The scientists in the SLEP study found that the vast majority of the drugs studied (88% representing 122 different drugs) maintained their potency and safety beyond the published expiration date by more than a year, with the average extension being 5.5 years, and a maximum extension of 23 years!

The most stable drugs are those in solid form such as tablets and capsules. Solutions or liquids lose their potency relatively quickly after their expiration dates.

An important caveat, certain medications have a narrow therapeutic index meaning that their safe and effective dose must be exact and kept within certain narrow parameters. Decreases or increases beyond these parameters can result in serious consequences. These types of drugs should not be used beyond their expiration date. An example of such drugs would be vancomycin and monoclonal antibodies.

The antibiotics included in the JASE Medical Emergency Antibiotic Kits are among those studied and shown to be safe and effective for at least 2 years beyond their published manufacturer expiration dates and in some cases for a lot longer. However, neither JASE Medical nor its partner pharmacies or drug manufacturers are included as participants of the FDA’s Shelf Life Extension Program and we therefore officially recommend and follow the manufacturer’s published expiration dates.

Check out these interesting and useful links from official sources:

FDA – Expiration Dating Extension

Journal of the American Medical Association (JAMA) – Drugs Past Their Expiration Date